{
  "url": "https://dantelabs.com/traits/abnormal-circulating-calcium-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-calcium-concentration",
    "id": "HP:0004363",
    "name": "Abnormal blood calcium levels",
    "label": "Abnormal circulating calcium concentration",
    "definition": "Any deviation from the normal concentration of calcium in the blood circulation.",
    "synonyms": [
      "Abnormal blood calcium concentration",
      "Abnormal calcium(2+) level",
      "Abnormal circulating Ca concentration",
      "Abnormal circulating Ca2+ concentration"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-inorganic-divalent-cation-concentration",
        "name": "Abnormal circulating inorganic divalent cation concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-inorganic-divalent-cation-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "hypercalcemia",
        "name": "High blood calcium levels",
        "genes": 83,
        "url": "https://dantelabs.com/traits/hypercalcemia"
      },
      {
        "slug": "hypocalcemia",
        "name": "Low blood calcium levels",
        "genes": 83,
        "url": "https://dantelabs.com/traits/hypocalcemia"
      }
    ],
    "genes": [
      {
        "slug": "phex",
        "symbol": "PHEX",
        "hgnc": "HGNC:8918",
        "name": "phosphate regulating endopeptidase X-linked",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phex"
      },
      {
        "slug": "adcy10",
        "symbol": "ADCY10",
        "hgnc": "HGNC:21285",
        "name": "adenylate cyclase 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adcy10"
      },
      {
        "slug": "slc34a2",
        "symbol": "SLC34A2",
        "hgnc": "HGNC:11020",
        "name": "solute carrier family 34 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a2"
      }
    ]
  }
}