{
  "url": "https://dantelabs.com/traits/abnormal-cerebral-cortex-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-cerebral-cortex-morphology",
    "id": "HP:0002538",
    "name": "Abnormal cerebral cortex morphology",
    "definition": "Any structural abnormality of the cerebral cortex.",
    "synonyms": [
      "Abnormality of the cerebral cortex"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cerebral-morphology",
        "name": "Abnormal cerebral morphology",
        "url": "https://dantelabs.com/traits/abnormal-cerebral-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "cerebral-cortical-atrophy",
        "name": "Decrease in size of the outer layer of the brain due to loss of brain cells",
        "genes": 320,
        "url": "https://dantelabs.com/traits/cerebral-cortical-atrophy"
      },
      {
        "slug": "cortical-dysplasia",
        "name": "Cortical dysplasia",
        "genes": 51,
        "url": "https://dantelabs.com/traits/cortical-dysplasia"
      },
      {
        "slug": "hypoplasia-of-the-frontal-lobes",
        "name": "Underdeveloped frontal lobe",
        "genes": 45,
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-frontal-lobes"
      },
      {
        "slug": "abnormal-cortical-gyration",
        "name": "Abnormal cortical gyration",
        "genes": 40,
        "url": "https://dantelabs.com/traits/abnormal-cortical-gyration"
      },
      {
        "slug": "thick-cerebral-cortex",
        "name": "Thick cerebral cortex",
        "genes": 12,
        "url": "https://dantelabs.com/traits/thick-cerebral-cortex"
      },
      {
        "slug": "neuronal-loss-in-the-cerebral-cortex",
        "name": "Neuronal loss in the cerebral cortex",
        "genes": 8,
        "url": "https://dantelabs.com/traits/neuronal-loss-in-the-cerebral-cortex"
      },
      {
        "slug": "small-cerebral-cortex",
        "name": "Small cerebral cortex",
        "genes": 8,
        "url": "https://dantelabs.com/traits/small-cerebral-cortex"
      },
      {
        "slug": "open-operculum",
        "name": "Open operculum",
        "genes": 6,
        "url": "https://dantelabs.com/traits/open-operculum"
      },
      {
        "slug": "cortical-tubers",
        "name": "Cortical tubers",
        "genes": 3,
        "url": "https://dantelabs.com/traits/cortical-tubers"
      },
      {
        "slug": "cerebral-cortex-with-spongiform-changes",
        "name": "Cerebral cortex with spongiform changes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cerebral-cortex-with-spongiform-changes"
      },
      {
        "slug": "abnormal-temporal-lobe-morphology",
        "name": "Abnormal temporal lobe morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-temporal-lobe-morphology"
      }
    ],
    "genes": [
      {
        "slug": "ermard",
        "symbol": "ERMARD",
        "hgnc": "HGNC:21056",
        "name": "ER membrane associated RNA degradation",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ermard"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "znf335",
        "symbol": "ZNF335",
        "hgnc": "HGNC:15807",
        "name": "zinc finger protein 335",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf335"
      },
      {
        "slug": "clp1",
        "symbol": "CLP1",
        "hgnc": "HGNC:16999",
        "name": "cleavage factor polyribonucleotide kinase subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clp1"
      },
      {
        "slug": "son",
        "symbol": "SON",
        "hgnc": "HGNC:11183",
        "name": "SON DNA and RNA binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/son"
      }
    ]
  }
}