{
  "url": "https://dantelabs.com/traits/abnormal-cd4-t-cell-subset-proportion",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-cd4-t-cell-subset-proportion",
    "id": "HP:0031392",
    "name": "Abnormal CD4+ T cell subset proportion",
    "definition": "Abnormal increase or decrease of any CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.",
    "synonyms": [
      "Abnormal CD4+ T cell subset",
      "Abnormal CD4+ T cell subsets",
      "Abnormal helper T cell proportion",
      "Abnormal proportion of CD4+ T cells",
      "Abnormal proportion of CD4-positive helper T cells",
      "Abnormal proportion of CD4-positive T cells",
      "Abnormal proportion of CD4-positive, alpha-beta T cells",
      "Abnormal proportion of circulating T-helper cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-t-cell-subset-number",
        "name": "Abnormal T cell subset number",
        "url": "https://dantelabs.com/traits/abnormal-t-cell-subset-number"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-naive-cd4-t-cell-proportion",
        "name": "Abnormal naive CD4+ T cell proportion",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-naive-cd4-t-cell-proportion"
      },
      {
        "slug": "abnormal-hla-dr-cd4-t-cell-proportion",
        "name": "Abnormal HLA-DR+ CD4+ T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-hla-dr-cd4-t-cell-proportion"
      },
      {
        "slug": "abnormal-memory-cd4-t-cell-proportion",
        "name": "Abnormal memory CD4+ T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-memory-cd4-t-cell-proportion"
      },
      {
        "slug": "abnormal-regulatory-t-cell-proportion",
        "name": "Abnormal regulatory T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-regulatory-t-cell-proportion"
      }
    ],
    "genes": [
      {
        "slug": "hla-dpb1",
        "symbol": "HLA-DPB1",
        "hgnc": "HGNC:4940",
        "name": "major histocompatibility complex, class II, DP beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpb1"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      }
    ]
  }
}