{
  "url": "https://dantelabs.com/traits/abnormal-bleeding",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-bleeding",
    "id": "HP:0001892",
    "name": "Bleeding tendency",
    "label": "Abnormal bleeding",
    "definition": "An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.",
    "synonyms": [
      "Bleeding diathesis",
      "Hemorrhagic diathesis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "narrower": [
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "genes": 110,
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "genes": 61,
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "prolonged-bleeding-time",
        "name": "Prolonged bleeding time",
        "genes": 48,
        "url": "https://dantelabs.com/traits/prolonged-bleeding-time"
      },
      {
        "slug": "menorrhagia",
        "name": "Abnormally heavy bleeding during menstruation",
        "genes": 43,
        "url": "https://dantelabs.com/traits/menorrhagia"
      },
      {
        "slug": "oral-cavity-bleeding",
        "name": "Oral cavity bleeding",
        "genes": 22,
        "url": "https://dantelabs.com/traits/oral-cavity-bleeding"
      },
      {
        "slug": "subcutaneous-hemorrhage",
        "name": "Bleeding below the skin",
        "genes": 15,
        "url": "https://dantelabs.com/traits/subcutaneous-hemorrhage"
      },
      {
        "slug": "persistent-bleeding-after-trauma",
        "name": "Excessive bleeding after minor trauma",
        "genes": 15,
        "url": "https://dantelabs.com/traits/persistent-bleeding-after-trauma"
      },
      {
        "slug": "cephalohematoma",
        "name": "Cephalohematoma",
        "genes": 13,
        "url": "https://dantelabs.com/traits/cephalohematoma"
      },
      {
        "slug": "internal-hemorrhage",
        "name": "Internal bleeding",
        "genes": 11,
        "url": "https://dantelabs.com/traits/internal-hemorrhage"
      },
      {
        "slug": "abnormal-umbilical-stump-bleeding",
        "name": "Abnormal umbilical stump bleeding",
        "genes": 10,
        "url": "https://dantelabs.com/traits/abnormal-umbilical-stump-bleeding"
      },
      {
        "slug": "bleeding-with-minor-or-no-trauma",
        "name": "Bleeding with minor or no trauma",
        "genes": 8,
        "url": "https://dantelabs.com/traits/bleeding-with-minor-or-no-trauma"
      },
      {
        "slug": "prolonged-bleeding-following-procedure",
        "name": "Prolonged bleeding following procedure",
        "genes": 7,
        "url": "https://dantelabs.com/traits/prolonged-bleeding-following-procedure"
      },
      {
        "slug": "excessive-bleeding-from-superficial-cuts",
        "name": "Excessive bleeding from superficial cuts",
        "genes": 5,
        "url": "https://dantelabs.com/traits/excessive-bleeding-from-superficial-cuts"
      },
      {
        "slug": "abnormal-vaginal-bleeding",
        "name": "Abnormal vaginal bleeding",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-vaginal-bleeding"
      },
      {
        "slug": "bleeding-requiring-red-cell-transfusion",
        "name": "Bleeding requiring red cell transfusion",
        "genes": 1,
        "url": "https://dantelabs.com/traits/bleeding-requiring-red-cell-transfusion"
      },
      {
        "slug": "excessive-bleeding-after-a-venipuncture",
        "name": "Excessive bleeding after a venipuncture",
        "genes": 1,
        "url": "https://dantelabs.com/traits/excessive-bleeding-after-a-venipuncture"
      },
      {
        "slug": "abnormal-onset-of-bleeding",
        "name": "Abnormal onset of bleeding",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-onset-of-bleeding"
      }
    ],
    "genes": [
      {
        "slug": "alg13",
        "symbol": "ALG13",
        "hgnc": "HGNC:30881",
        "name": "ALG13 UDP-N-acetylglucosaminyltransferase subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg13"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "fga",
        "symbol": "FGA",
        "hgnc": "HGNC:3661",
        "name": "fibrinogen alpha chain",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fga"
      },
      {
        "slug": "fgb",
        "symbol": "FGB",
        "hgnc": "HGNC:3662",
        "name": "fibrinogen beta chain",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgb"
      },
      {
        "slug": "fgg",
        "symbol": "FGG",
        "hgnc": "HGNC:3694",
        "name": "fibrinogen gamma chain",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgg"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "hgnc": "HGNC:4036",
        "name": "FYN binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fyb1"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "hgnc": "HGNC:4116",
        "name": "UDP-galactose-4-epimerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gale"
      },
      {
        "slug": "gfi1b",
        "symbol": "GFI1B",
        "hgnc": "HGNC:4238",
        "name": "growth factor independent 1B transcriptional repressor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfi1b"
      },
      {
        "slug": "hps3",
        "symbol": "HPS3",
        "hgnc": "HGNC:15597",
        "name": "HPS3 biogenesis of lysosomal organelles complex 2 subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps3"
      },
      {
        "slug": "hps4",
        "symbol": "HPS4",
        "hgnc": "HGNC:15844",
        "name": "HPS4 biogenesis of lysosomal organelles complex 3 subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps4"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "prkacg",
        "symbol": "PRKACG",
        "hgnc": "HGNC:9382",
        "name": "protein kinase cAMP-activated catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkacg"
      },
      {
        "slug": "ptprj",
        "symbol": "PTPRJ",
        "hgnc": "HGNC:9673",
        "name": "protein tyrosine phosphatase receptor type J",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprj"
      },
      {
        "slug": "arf1",
        "symbol": "ARF1",
        "hgnc": "HGNC:652",
        "name": "ARF GTPase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arf1"
      },
      {
        "slug": "arfgef2",
        "symbol": "ARFGEF2",
        "hgnc": "HGNC:15853",
        "name": "ARF guanine nucleotide exchange factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arfgef2"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "chst14",
        "symbol": "CHST14",
        "hgnc": "HGNC:24464",
        "name": "carbohydrate sulfotransferase 14",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst14"
      },
      {
        "slug": "dse",
        "symbol": "DSE",
        "hgnc": "HGNC:21144",
        "name": "dermatan sulfate epimerase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dse"
      },
      {
        "slug": "eng",
        "symbol": "ENG",
        "hgnc": "HGNC:3349",
        "name": "endoglin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eng"
      },
      {
        "slug": "ermard",
        "symbol": "ERMARD",
        "hgnc": "HGNC:21056",
        "name": "ER membrane associated RNA degradation",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ermard"
      },
      {
        "slug": "f11",
        "symbol": "F11",
        "hgnc": "HGNC:3529",
        "name": "coagulation factor XI",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f11"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "map1b",
        "symbol": "MAP1B",
        "hgnc": "HGNC:6836",
        "name": "microtubule associated protein 1B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map1b"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "nbeal2",
        "symbol": "NBEAL2",
        "hgnc": "HGNC:31928",
        "name": "neurobeachin like 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nbeal2"
      },
      {
        "slug": "nedd4l",
        "symbol": "NEDD4L",
        "hgnc": "HGNC:7728",
        "name": "NEDD4 like E3 ubiquitin protein ligase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nedd4l"
      },
      {
        "slug": "slc35a1",
        "symbol": "SLC35A1",
        "hgnc": "HGNC:11021",
        "name": "solute carrier family 35 member A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a1"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "thpo",
        "symbol": "THPO",
        "hgnc": "HGNC:11795",
        "name": "thrombopoietin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/thpo"
      },
      {
        "slug": "tmtc3",
        "symbol": "TMTC3",
        "hgnc": "HGNC:26899",
        "name": "transmembrane O-mannosyltransferase targeting cadherins 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmtc3"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "cd109",
        "symbol": "CD109",
        "hgnc": "HGNC:21685",
        "name": "CD109 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd109"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "hgnc": "HGNC:3535",
        "name": "coagulation factor II, thrombin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "fip1l1",
        "symbol": "FIP1L1",
        "hgnc": "HGNC:19124",
        "name": "factor interacting with PAPOLA and CPSF1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fip1l1"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "hgnc": "HGNC:21729",
        "name": "interferon regulatory factor 2 binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf2bp2"
      },
      {
        "slug": "itga2",
        "symbol": "ITGA2",
        "hgnc": "HGNC:6137",
        "name": "integrin subunit alpha 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga2"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "lztr1",
        "symbol": "LZTR1",
        "hgnc": "HGNC:6742",
        "name": "leucine zipper like post translational regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lztr1"
      },
      {
        "slug": "mras",
        "symbol": "MRAS",
        "hgnc": "HGNC:7227",
        "name": "muscle RAS oncogene homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mras"
      },
      {
        "slug": "nabp1",
        "symbol": "NABP1",
        "hgnc": "HGNC:26232",
        "name": "nucleic acid binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nabp1"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "numa1",
        "symbol": "NUMA1",
        "hgnc": "HGNC:8059",
        "name": "nuclear mitotic apparatus protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/numa1"
      },
      {
        "slug": "pml",
        "symbol": "PML",
        "hgnc": "HGNC:9113",
        "name": "PML nuclear body scaffold",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pml"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "hgnc": "HGNC:9644",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ptpn11"
      },
      {
        "slug": "raf1",
        "symbol": "RAF1",
        "hgnc": "HGNC:9829",
        "name": "Raf-1 proto-oncogene, serine/threonine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/raf1"
      },
      {
        "slug": "rara",
        "symbol": "RARA",
        "hgnc": "HGNC:9864",
        "name": "retinoic acid receptor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rara"
      },
      {
        "slug": "rasa2",
        "symbol": "RASA2",
        "hgnc": "HGNC:9872",
        "name": "RAS p21 protein activator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasa2"
      },
      {
        "slug": "rft1",
        "symbol": "RFT1",
        "hgnc": "HGNC:30220",
        "name": "RFT1 glycolipid translocator homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rft1"
      },
      {
        "slug": "rit1",
        "symbol": "RIT1",
        "hgnc": "HGNC:10023",
        "name": "Ras like without CAAX 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rit1"
      },
      {
        "slug": "rras",
        "symbol": "RRAS",
        "hgnc": "HGNC:10447",
        "name": "RAS related",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rras"
      },
      {
        "slug": "rras2",
        "symbol": "RRAS2",
        "hgnc": "HGNC:17271",
        "name": "RAS related 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rras2"
      },
      {
        "slug": "serpinf2",
        "symbol": "SERPINF2",
        "hgnc": "HGNC:9075",
        "name": "serpin family F member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinf2"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "sos1",
        "symbol": "SOS1",
        "hgnc": "HGNC:11187",
        "name": "SOS Ras/Rac guanine nucleotide exchange factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sos1"
      },
      {
        "slug": "sos2",
        "symbol": "SOS2",
        "hgnc": "HGNC:11188",
        "name": "SOS Ras/Rho guanine nucleotide exchange factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sos2"
      },
      {
        "slug": "spred2",
        "symbol": "SPRED2",
        "hgnc": "HGNC:17722",
        "name": "sprouty related EVH1 domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spred2"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vkorc1"
      },
      {
        "slug": "zbtb16",
        "symbol": "ZBTB16",
        "hgnc": "HGNC:12930",
        "name": "zinc finger and BTB domain containing 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb16"
      },
      {
        "slug": "alk",
        "symbol": "ALK",
        "hgnc": "HGNC:427",
        "name": "ALK receptor tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alk"
      },
      {
        "slug": "amn",
        "symbol": "AMN",
        "hgnc": "HGNC:14604",
        "name": "amnion associated transmembrane protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amn"
      },
      {
        "slug": "b4galt1",
        "symbol": "B4GALT1",
        "hgnc": "HGNC:924",
        "name": "beta-1,4-galactosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt1"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "cog6",
        "symbol": "COG6",
        "hgnc": "HGNC:18621",
        "name": "component of oligomeric golgi complex 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog6"
      },
      {
        "slug": "cubn",
        "symbol": "CUBN",
        "hgnc": "HGNC:2548",
        "name": "cubilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cubn"
      },
      {
        "slug": "epor",
        "symbol": "EPOR",
        "hgnc": "HGNC:3416",
        "name": "erythropoietin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epor"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "hace1",
        "symbol": "HACE1",
        "hgnc": "HGNC:21033",
        "name": "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hace1"
      },
      {
        "slug": "hsd3b7",
        "symbol": "HSD3B7",
        "hgnc": "HGNC:18324",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd3b7"
      },
      {
        "slug": "ipo8",
        "symbol": "IPO8",
        "hgnc": "HGNC:9853",
        "name": "importin 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ipo8"
      },
      {
        "slug": "lin28b",
        "symbol": "LIN28B",
        "hgnc": "HGNC:32207",
        "name": "lin-28 RNA binding posttranscriptional regulator B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lin28b"
      },
      {
        "slug": "lmo1",
        "symbol": "LMO1",
        "hgnc": "HGNC:6641",
        "name": "LIM domain only 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmo1"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "hgnc": "HGNC:6840",
        "name": "mitogen-activated protein kinase kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k1"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "mycn",
        "symbol": "MYCN",
        "hgnc": "HGNC:7559",
        "name": "MYCN proto-oncogene, bHLH transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mycn"
      },
      {
        "slug": "phox2b",
        "symbol": "PHOX2B",
        "hgnc": "HGNC:9143",
        "name": "paired like homeobox 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phox2b"
      },
      {
        "slug": "plod1",
        "symbol": "PLOD1",
        "hgnc": "HGNC:9081",
        "name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plod1"
      },
      {
        "slug": "rasa1",
        "symbol": "RASA1",
        "hgnc": "HGNC:9871",
        "name": "RAS p21 protein activator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasa1"
      },
      {
        "slug": "rps14",
        "symbol": "RPS14",
        "hgnc": "HGNC:10387",
        "name": "ribosomal protein S14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps14"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "smad2",
        "symbol": "SMAD2",
        "hgnc": "HGNC:6768",
        "name": "SMAD family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad2"
      },
      {
        "slug": "smad3",
        "symbol": "SMAD3",
        "hgnc": "HGNC:6769",
        "name": "SMAD family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad3"
      },
      {
        "slug": "tgfb2",
        "symbol": "TGFB2",
        "hgnc": "HGNC:11768",
        "name": "transforming growth factor beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb2"
      },
      {
        "slug": "tgfb3",
        "symbol": "TGFB3",
        "hgnc": "HGNC:11769",
        "name": "transforming growth factor beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb3"
      },
      {
        "slug": "tgfbr1",
        "symbol": "TGFBR1",
        "hgnc": "HGNC:11772",
        "name": "transforming growth factor beta receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbr1"
      },
      {
        "slug": "tgfbr2",
        "symbol": "TGFBR2",
        "hgnc": "HGNC:11773",
        "name": "transforming growth factor beta receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbr2"
      },
      {
        "slug": "urod",
        "symbol": "UROD",
        "hgnc": "HGNC:12591",
        "name": "uroporphyrinogen decarboxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/urod"
      },
      {
        "slug": "uros",
        "symbol": "UROS",
        "hgnc": "HGNC:12592",
        "name": "uroporphyrinogen III synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uros"
      },
      {
        "slug": "vps33b",
        "symbol": "VPS33B",
        "hgnc": "HGNC:12712",
        "name": "VPS33B late endosome and lysosome associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33b"
      },
      {
        "slug": "f12",
        "symbol": "F12",
        "hgnc": "HGNC:3530",
        "name": "coagulation factor XII",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f12"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "sf3b1",
        "symbol": "SF3B1",
        "hgnc": "HGNC:10768",
        "name": "splicing factor 3b subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b1"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "ano6",
        "symbol": "ANO6",
        "hgnc": "HGNC:25240",
        "name": "anoctamin 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano6"
      },
      {
        "slug": "cd36",
        "symbol": "CD36",
        "hgnc": "HGNC:1663",
        "name": "CD36 molecule (CD36 blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd36"
      },
      {
        "slug": "cisd2",
        "symbol": "CISD2",
        "hgnc": "HGNC:24212",
        "name": "CDGSH iron sulfur domain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cisd2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "fermt3",
        "symbol": "FERMT3",
        "hgnc": "HGNC:23151",
        "name": "FERM domain containing kindlin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt3"
      },
      {
        "slug": "g6pc1",
        "symbol": "G6PC1",
        "hgnc": "HGNC:4056",
        "name": "glucose-6-phosphatase catalytic subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pc1"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "mpi",
        "symbol": "MPI",
        "hgnc": "HGNC:7216",
        "name": "mannose phosphate isomerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpi"
      },
      {
        "slug": "myh9",
        "symbol": "MYH9",
        "hgnc": "HGNC:7579",
        "name": "myosin heavy chain 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh9"
      },
      {
        "slug": "p2ry12",
        "symbol": "P2RY12",
        "hgnc": "HGNC:18124",
        "name": "purinergic receptor P2Y12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p2ry12"
      },
      {
        "slug": "pex12",
        "symbol": "PEX12",
        "hgnc": "HGNC:8854",
        "name": "peroxisomal biogenesis factor 12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex12"
      },
      {
        "slug": "serpine1",
        "symbol": "SERPINE1",
        "hgnc": "HGNC:8583",
        "name": "serpin family E member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpine1"
      },
      {
        "slug": "src",
        "symbol": "SRC",
        "hgnc": "HGNC:11283",
        "name": "SRC proto-oncogene, non-receptor tyrosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/src"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "vwf",
        "symbol": "VWF",
        "hgnc": "HGNC:12726",
        "name": "von Willebrand factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vwf"
      }
    ]
  }
}