{
  "url": "https://dantelabs.com/traits/3-hydroxyisovaleric-aciduria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "3-hydroxyisovaleric-aciduria",
    "id": "HP:0033111",
    "name": "3-hydroxyisovaleric aciduria",
    "definition": "Concentration of 3-hydroxyisovaleric acid in the urine above the normal range.",
    "synonyms": [
      "Increased urine 3-hydroxyisovaleric acid level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "organic-aciduria",
        "name": "Organic aciduria",
        "url": "https://dantelabs.com/traits/organic-aciduria"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "hlcs",
        "symbol": "HLCS",
        "hgnc": "HGNC:4976",
        "name": "holocarboxylase synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hlcs"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "hgnc": "HGNC:6936",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc1"
      },
      {
        "slug": "ivd",
        "symbol": "IVD",
        "hgnc": "HGNC:6186",
        "name": "isovaleryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivd"
      }
    ]
  }
}