{
  "url": "https://dantelabs.com/de/genes/plcz1",
  "gene": {
    "slug": "plcz1",
    "symbol": "PLCZ1",
    "name": "phospholipase C zeta 1",
    "hgnc": "HGNC:19218",
    "summary": null,
    "location": "12p12.3",
    "locusType": "gene with protein product",
    "aliases": [
      "NYD-SP27",
      "PLCzeta",
      "Czeta"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000139151",
    "entrezId": 89869,
    "omim": [
      "608075"
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    "uniprot": [
      "Q86YW0"
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 18683180,
      "end": 18738012,
      "strand": "-",
      "ensemblTranscript": "ENST00000266505.12",
      "refseqTranscript": "NM_033123.4",
      "ensemblProtein": "ENSP00000266505.7",
      "refseqProtein": "NP_149114.2",
      "exons": [
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        {
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      ],
      "cds": {
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
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      "end": 18890991,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "RERGL",
          "ensemblId": "ENSG00000111404",
          "biotype": "protein_coding",
          "start": 18080869,
          "end": 18320107,
          "strand": "-",
          "slug": "rergl"
        },
        {
          "symbol": "PIK3C2G",
          "ensemblId": "ENSG00000139144",
          "biotype": "protein_coding",
          "start": 18242947,
          "end": 18648416,
          "strand": "+",
          "slug": "pik3c2g"
        },
        {
          "symbol": "CAPZA3",
          "ensemblId": "ENSG00000177938",
          "biotype": "protein_coding",
          "start": 18738119,
          "end": 18742920,
          "strand": "+",
          "slug": "capza3"
        },
        {
          "symbol": "PLEKHA5",
          "ensemblId": "ENSG00000052126",
          "biotype": "protein_coding",
          "start": 19129513,
          "end": 19376403,
          "strand": "+",
          "slug": "plekha5"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "male-infertility",
        "name": "Männliche Unfruchtbarkeit",
        "diseases": [
          {
            "mondoId": "MONDO:0005372",
            "name": "Männliche Unfruchtbarkeit",
            "genes": 41,
            "inheritance": null,
            "description": "Die Unfähigkeit des Mannes, nach einem bestimmten Zeitraum mit ungeschütztem Geschlechtsverkehr eine Eizelle zu befruchten. Bei der männlichen Sterilität handelt es sich um eine dauerhafte Unfruchtbarkeit.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/de/conditions/male-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      }
    ],
    "related": [
      {
        "slug": "actl9",
        "symbol": "ACTL9",
        "name": "actin like 9",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/actl9"
      },
      {
        "slug": "armc2",
        "symbol": "ARMC2",
        "name": "armadillo repeat containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/armc2"
      },
      {
        "slug": "aurkc",
        "symbol": "AURKC",
        "name": "aurora kinase C",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/aurkc"
      },
      {
        "slug": "bcorl1",
        "symbol": "BCORL1",
        "name": "BCL6 corepressor like 1",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/bcorl1"
      },
      {
        "slug": "cfap251",
        "symbol": "CFAP251",
        "name": "cilia and flagella associated protein 251",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/cfap251"
      },
      {
        "slug": "cfap43",
        "symbol": "CFAP43",
        "name": "cilia and flagella associated protein 43",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/cfap43"
      },
      {
        "slug": "dmc1",
        "symbol": "DMC1",
        "name": "DNA meiotic recombinase 1",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dmc1"
      },
      {
        "slug": "dmrt1",
        "symbol": "DMRT1",
        "name": "doublesex and mab-3 related transcription factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dmrt1"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "name": "dynein axonemal heavy chain 1",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dnah1"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "name": "dynein axonemal heavy chain 10",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dnah10"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "name": "dynein axonemal heavy chain 12",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dnah12"
      },
      {
        "slug": "dnah17",
        "symbol": "DNAH17",
        "name": "dynein axonemal heavy chain 17",
        "shared": 1,
        "url": "https://dantelabs.com/de/genes/dnah17"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}