{
  "url": "https://dantelabs.com/de/genes/neurog1",
  "gene": {
    "slug": "neurog1",
    "symbol": "NEUROG1",
    "name": "neurogenin 1",
    "hgnc": "HGNC:7764",
    "summary": null,
    "location": "5q31.1",
    "locusType": "gene with protein product",
    "aliases": [
      "AKA",
      "Math4C",
      "ngn1",
      "bHLHa6"
    ],
    "previousSymbols": [
      "NEUROD3"
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    "ensemblId": "ENSG00000181965",
    "entrezId": 4762,
    "omim": [
      "601726"
    ],
    "uniprot": [
      "Q92886"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "5",
      "start": 135534282,
      "end": 135535964,
      "strand": "-",
      "ensemblTranscript": "ENST00000314744.6",
      "refseqTranscript": "NM_006161.3",
      "ensemblProtein": "ENSP00000317580.4",
      "refseqProtein": "NP_006152.2",
      "exons": [
        {
          "start": 135534282,
          "end": 135535964
        }
      ],
      "cds": {
        "start": 135534977,
        "end": 135535690
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
      "start": 134869991,
      "end": 134871639,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 135035123,
      "end": 136035122,
      "genes": [
        {
          "symbol": "MACROH2A1",
          "ensemblId": "ENSG00000113648",
          "biotype": "protein_coding",
          "start": 135332641,
          "end": 135400023,
          "strand": "-",
          "slug": "macroh2a1"
        },
        {
          "symbol": "DCANP1",
          "ensemblId": "ENSG00000251380",
          "biotype": "protein_coding",
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          "end": 135447348,
          "strand": "-",
          "slug": "dcanp1"
        },
        {
          "symbol": "TIFAB",
          "ensemblId": "ENSG00000255833",
          "biotype": "protein_coding",
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          "end": 135452388,
          "strand": "-",
          "slug": "tifab"
        },
        {
          "symbol": "SLC25A48",
          "ensemblId": "ENSG00000145832",
          "biotype": "protein_coding",
          "start": 135476913,
          "end": 135890730,
          "strand": "+",
          "slug": "slc25a48"
        },
        {
          "symbol": "CXCL14",
          "ensemblId": "ENSG00000145824",
          "biotype": "protein_coding",
          "start": 135570679,
          "end": 135579580,
          "strand": "-",
          "slug": "cxcl14"
        },
        {
          "symbol": "IL9",
          "ensemblId": "ENSG00000145839",
          "biotype": "protein_coding",
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          "end": 135895841,
          "strand": "-",
          "slug": "il9"
        },
        {
          "symbol": "LECT2",
          "ensemblId": "ENSG00000145826",
          "biotype": "protein_coding",
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          "end": 135955061,
          "strand": "-",
          "slug": "lect2"
        },
        {
          "symbol": "TGFBI",
          "ensemblId": "ENSG00000120708",
          "biotype": "protein_coding",
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          "end": 136103902,
          "strand": "+",
          "slug": "tgfbi"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "absent-corneal-reflex",
        "name": "Absent corneal reflex",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-corneal-reflex"
      },
      {
        "slug": "absent-internal-auditory-canal",
        "name": "Absent internal auditory canal",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/absent-internal-auditory-canal"
      },
      {
        "slug": "areflexia",
        "name": "Absent reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/areflexia"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "long-palpebral-fissure",
        "name": "Broad opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/long-palpebral-fissure"
      },
      {
        "slug": "impaired-mastication",
        "name": "Chewing difficulties",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/impaired-mastication"
      },
      {
        "slug": "corneal-opacity",
        "name": "Corneal opacity",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/corneal-opacity"
      },
      {
        "slug": "insomnia",
        "name": "Difficulty staying or falling asleep",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/insomnia"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "mask-like-facies",
        "name": "Expressionless face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mask-like-facies"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "flat-occiput",
        "name": "Flat back of skull",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/flat-occiput"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "highly-arched-eyebrow",
        "name": "Highly arched eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/highly-arched-eyebrow"
      },
      {
        "slug": "hyperkinetic-movements",
        "name": "Hyperactive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperkinetic-movements"
      },
      {
        "slug": "hyperintensity-of-cerebral-white-matter-on-mri",
        "name": "Hyperintensity of cerebral white matter on MRI",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperintensity-of-cerebral-white-matter-on-mri"
      },
      {
        "slug": "hypoplasia-of-the-cochlea",
        "name": "Hypoplasia of the cochlea",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-cochlea"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "myoclonic-seizure",
        "name": "Myoclonic seizure",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/myoclonic-seizure"
      },
      {
        "slug": "narrow-palate",
        "name": "Narrow palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/narrow-palate"
      },
      {
        "slug": "profound-global-developmental-delay",
        "name": "Profound global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/profound-global-developmental-delay"
      },
      {
        "slug": "profound-sensorineural-hearing-impairment",
        "name": "Profound sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/profound-sensorineural-hearing-impairment"
      },
      {
        "slug": "self-injurious-behavior",
        "name": "Self-injurious behavior",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/self-injurious-behavior"
      },
      {
        "slug": "sensory-axonal-neuropathy",
        "name": "Sensory axonal neuropathy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sensory-axonal-neuropathy"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}