{
  "url": "https://dantelabs.com/de/genes/cyb561",
  "gene": {
    "slug": "cyb561",
    "symbol": "CYB561",
    "name": "cytochrome b561",
    "hgnc": "HGNC:2571",
    "summary": null,
    "location": "17q23.3",
    "locusType": "gene with protein product",
    "aliases": [
      "FRRS2",
      "CYB561A1",
      "CGCytb"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000008283",
    "entrezId": 1534,
    "omim": [
      "600019"
    ],
    "uniprot": [
      "P49447"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 63432304,
      "end": 63446306,
      "strand": "-",
      "ensemblTranscript": "ENST00000360793.8",
      "refseqTranscript": "NM_001915.4",
      "ensemblProtein": "ENSP00000354028.3",
      "refseqProtein": "NP_001906.3",
      "exons": [
        {
          "start": 63432304,
          "end": 63434594
        },
        {
          "start": 63435086,
          "end": 63435243
        },
        {
          "start": 63435688,
          "end": 63435791
        },
        {
          "start": 63436054,
          "end": 63436152
        },
        {
          "start": 63437346,
          "end": 63437560
        },
        {
          "start": 63446245,
          "end": 63446306
        }
      ],
      "cds": {
        "start": 63434402,
        "end": 63437547
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 61509665,
      "end": 61523739,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 62939305,
      "end": 63939304,
      "genes": [
        {
          "symbol": "TANC2",
          "ensemblId": "ENSG00000170921",
          "biotype": "protein_coding",
          "start": 62966201,
          "end": 63427703,
          "strand": "+",
          "slug": "tanc2"
        },
        {
          "symbol": "ACE",
          "ensemblId": "ENSG00000159640",
          "biotype": "protein_coding",
          "start": 63477058,
          "end": 63498380,
          "strand": "+",
          "slug": "ace"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000264813",
          "biotype": "protein_coding",
          "start": 63484823,
          "end": 63521848,
          "strand": "+"
        },
        {
          "symbol": "KCNH6",
          "ensemblId": "ENSG00000173826",
          "biotype": "protein_coding",
          "start": 63523310,
          "end": 63548987,
          "strand": "+",
          "slug": "kcnh6"
        },
        {
          "symbol": "DCAF7",
          "ensemblId": "ENSG00000136485",
          "biotype": "protein_coding",
          "start": 63550222,
          "end": 63594286,
          "strand": "+",
          "slug": "dcaf7"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288894",
          "biotype": "protein_coding",
          "start": 63550603,
          "end": 63608347,
          "strand": "+"
        },
        {
          "symbol": "TACO1",
          "ensemblId": "ENSG00000136463",
          "biotype": "protein_coding",
          "start": 63600879,
          "end": 63612023,
          "strand": "+",
          "slug": "taco1"
        },
        {
          "symbol": "MAP3K3",
          "ensemblId": "ENSG00000198909",
          "biotype": "protein_coding",
          "start": 63622379,
          "end": 63696310,
          "strand": "+",
          "slug": "map3k3"
        },
        {
          "symbol": "STRADA",
          "ensemblId": "ENSG00000266173",
          "biotype": "protein_coding",
          "start": 63682336,
          "end": 63742005,
          "strand": "-",
          "slug": "strada"
        },
        {
          "symbol": "LIMD2",
          "ensemblId": "ENSG00000136490",
          "biotype": "protein_coding",
          "start": 63695883,
          "end": 63701183,
          "strand": "-",
          "slug": "limd2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000125695",
          "biotype": "protein_coding",
          "start": 63702845,
          "end": 63752097,
          "strand": "-"
        },
        {
          "symbol": "CCDC47",
          "ensemblId": "ENSG00000108588",
          "biotype": "protein_coding",
          "start": 63745250,
          "end": 63776351,
          "strand": "-",
          "slug": "ccdc47"
        },
        {
          "symbol": "DDX42",
          "ensemblId": "ENSG00000198231",
          "biotype": "protein_coding",
          "start": 63773603,
          "end": 63820451,
          "strand": "+",
          "slug": "ddx42"
        },
        {
          "symbol": "FTSJ3",
          "ensemblId": "ENSG00000108592",
          "biotype": "protein_coding",
          "start": 63819113,
          "end": 63830012,
          "strand": "-",
          "slug": "ftsj3"
        },
        {
          "symbol": "PSMC5",
          "ensemblId": "ENSG00000087191",
          "biotype": "protein_coding",
          "start": 63827082,
          "end": 63832244,
          "strand": "+",
          "slug": "psmc5"
        },
        {
          "symbol": "SMARCD2",
          "ensemblId": "ENSG00000108604",
          "biotype": "protein_coding",
          "start": 63832078,
          "end": 63843065,
          "strand": "-",
          "slug": "smarcd2"
        },
        {
          "symbol": "CSH2",
          "ensemblId": "ENSG00000213218",
          "biotype": "protein_coding",
          "start": 63872007,
          "end": 63873769,
          "strand": "-",
          "slug": "csh2"
        },
        {
          "symbol": "GH2",
          "ensemblId": "ENSG00000136487",
          "biotype": "protein_coding",
          "start": 63880205,
          "end": 63881970,
          "strand": "-",
          "slug": "gh2"
        },
        {
          "symbol": "CSH1",
          "ensemblId": "ENSG00000136488",
          "biotype": "protein_coding",
          "start": 63894906,
          "end": 63896667,
          "strand": "-",
          "slug": "csh1"
        },
        {
          "symbol": "CSHL1",
          "ensemblId": "ENSG00000204414",
          "biotype": "protein_coding",
          "start": 63909596,
          "end": 63911348,
          "strand": "-",
          "slug": "cshl1"
        },
        {
          "symbol": "GH1",
          "ensemblId": "ENSG00000259384",
          "biotype": "protein_coding",
          "start": 63917200,
          "end": 63918839,
          "strand": "-",
          "slug": "gh1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285947",
          "biotype": "protein_coding",
          "start": 63917203,
          "end": 63931385,
          "strand": "-"
        },
        {
          "symbol": "CD79B",
          "ensemblId": "ENSG00000007312",
          "biotype": "protein_coding",
          "start": 63928738,
          "end": 63932629,
          "strand": "-",
          "slug": "cd79b"
        },
        {
          "symbol": "SCN4A",
          "ensemblId": "ENSG00000007314",
          "biotype": "protein_coding",
          "start": 63938554,
          "end": 63972918,
          "strand": "-",
          "slug": "scn4a"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "orthostatic-hypotension",
        "name": "Decrease in blood pressure upon standing up",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/orthostatic-hypotension"
      },
      {
        "slug": "decreased-glomerular-filtration-rate",
        "name": "Decreased glomerular filtration rate",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-glomerular-filtration-rate"
      },
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypoglycemia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}