{
  "url": "https://dantelabs.com/de/genes/ccdc22",
  "gene": {
    "slug": "ccdc22",
    "symbol": "CCDC22",
    "name": "CCC complex scaffolding subunit CCDC22",
    "hgnc": "HGNC:28909",
    "summary": null,
    "location": "Xp11.23",
    "locusType": "gene with protein product",
    "aliases": [
      "JM1"
    ],
    "previousSymbols": [
      "CXorf37"
    ],
    "ensemblId": "ENSG00000101997",
    "entrezId": 28952,
    "omim": [
      "300859"
    ],
    "uniprot": [
      "O60826"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "X",
      "start": 49235470,
      "end": 49250520,
      "strand": "+",
      "ensemblTranscript": "ENST00000376227.4",
      "refseqTranscript": "NM_014008.5",
      "ensemblProtein": "ENSP00000365401.3",
      "refseqProtein": "NP_054727.1",
      "exons": [
        {
          "start": 49235470,
          "end": 49235686
        },
        {
          "start": 49237086,
          "end": 49237263
        },
        {
          "start": 49242016,
          "end": 49242148
        },
        {
          "start": 49242886,
          "end": 49242992
        },
        {
          "start": 49243118,
          "end": 49243184
        },
        {
          "start": 49243284,
          "end": 49243462
        },
        {
          "start": 49246731,
          "end": 49246925
        },
        {
          "start": 49247496,
          "end": 49247558
        },
        {
          "start": 49247649,
          "end": 49247768
        },
        {
          "start": 49248191,
          "end": 49248310
        },
        {
          "start": 49248407,
          "end": 49248523
        },
        {
          "start": 49248633,
          "end": 49248734
        },
        {
          "start": 49248817,
          "end": 49248924
        },
        {
          "start": 49249167,
          "end": 49249262
        },
        {
          "start": 49249509,
          "end": 49249568
        },
        {
          "start": 49249651,
          "end": 49249725
        },
        {
          "start": 49250148,
          "end": 49250520
        }
      ],
      "cds": {
        "start": 49235637,
        "end": 49250261
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
      "start": 49091927,
      "end": 49106987,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 48742995,
      "end": 49742994,
      "genes": [
        {
          "symbol": "GLOD5",
          "ensemblId": "ENSG00000171433",
          "biotype": "protein_coding",
          "start": 48761744,
          "end": 48773648,
          "strand": "+",
          "slug": "glod5"
        },
        {
          "symbol": "GATA1",
          "ensemblId": "ENSG00000102145",
          "biotype": "protein_coding",
          "start": 48783122,
          "end": 48794311,
          "strand": "+",
          "slug": "gata1"
        },
        {
          "symbol": "HDAC6",
          "ensemblId": "ENSG00000094631",
          "biotype": "protein_coding",
          "start": 48801372,
          "end": 48824986,
          "strand": "+",
          "slug": "hdac6"
        },
        {
          "symbol": "ERAS",
          "ensemblId": "ENSG00000187682",
          "biotype": "protein_coding",
          "start": 48826513,
          "end": 48830138,
          "strand": "+",
          "slug": "eras"
        },
        {
          "symbol": "PCSK1N",
          "ensemblId": "ENSG00000102109",
          "biotype": "protein_coding",
          "start": 48831088,
          "end": 48835632,
          "strand": "-",
          "slug": "pcsk1n"
        },
        {
          "symbol": "TIMM17B",
          "ensemblId": "ENSG00000126768",
          "biotype": "protein_coding",
          "start": 48880274,
          "end": 48898143,
          "strand": "-",
          "slug": "timm17b"
        },
        {
          "symbol": "PQBP1",
          "ensemblId": "ENSG00000102103",
          "biotype": "protein_coding",
          "start": 48890197,
          "end": 48903640,
          "strand": "+",
          "slug": "pqbp1"
        },
        {
          "symbol": "SLC35A2",
          "ensemblId": "ENSG00000102100",
          "biotype": "protein_coding",
          "start": 48903180,
          "end": 48911958,
          "strand": "-",
          "slug": "slc35a2"
        },
        {
          "symbol": "PIM2",
          "ensemblId": "ENSG00000102096",
          "biotype": "protein_coding",
          "start": 48913172,
          "end": 48919546,
          "strand": "-",
          "slug": "pim2"
        },
        {
          "symbol": "OTUD5",
          "ensemblId": "ENSG00000068308",
          "biotype": "protein_coding",
          "start": 48922024,
          "end": 48958390,
          "strand": "-",
          "slug": "otud5"
        },
        {
          "symbol": "KCND1",
          "ensemblId": "ENSG00000102057",
          "biotype": "protein_coding",
          "start": 48960982,
          "end": 48971916,
          "strand": "-",
          "slug": "kcnd1"
        },
        {
          "symbol": "GRIPAP1",
          "ensemblId": "ENSG00000068400",
          "biotype": "protein_coding",
          "start": 48973719,
          "end": 49002265,
          "strand": "-",
          "slug": "gripap1"
        },
        {
          "symbol": "TFE3",
          "ensemblId": "ENSG00000068323",
          "biotype": "protein_coding",
          "start": 49028726,
          "end": 49043512,
          "strand": "-",
          "slug": "tfe3"
        },
        {
          "symbol": "CCDC120",
          "ensemblId": "ENSG00000147144",
          "biotype": "protein_coding",
          "start": 49053463,
          "end": 49073357,
          "strand": "+",
          "slug": "ccdc120"
        },
        {
          "symbol": "PRAF2",
          "ensemblId": "ENSG00000243279",
          "biotype": "protein_coding",
          "start": 49070107,
          "end": 49074022,
          "strand": "-",
          "slug": "praf2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288053",
          "biotype": "protein_coding",
          "start": 49071470,
          "end": 49079887,
          "strand": "-"
        },
        {
          "symbol": "WDR45",
          "ensemblId": "ENSG00000196998",
          "biotype": "protein_coding",
          "start": 49074431,
          "end": 49101203,
          "strand": "-",
          "slug": "wdr45"
        },
        {
          "symbol": "GPKOW",
          "ensemblId": "ENSG00000068394",
          "biotype": "protein_coding",
          "start": 49112941,
          "end": 49123750,
          "strand": "-",
          "slug": "gpkow"
        },
        {
          "symbol": "MAGIX",
          "ensemblId": "ENSG00000269313",
          "biotype": "protein_coding",
          "start": 49162564,
          "end": 49169931,
          "strand": "+",
          "slug": "magix"
        },
        {
          "symbol": "PLP2",
          "ensemblId": "ENSG00000102007",
          "biotype": "protein_coding",
          "start": 49171787,
          "end": 49175387,
          "strand": "+",
          "slug": "plp2"
        },
        {
          "symbol": "PRICKLE3",
          "ensemblId": "ENSG00000012211",
          "biotype": "protein_coding",
          "start": 49174802,
          "end": 49186528,
          "strand": "-",
          "slug": "prickle3"
        },
        {
          "symbol": "SYP",
          "ensemblId": "ENSG00000102003",
          "biotype": "protein_coding",
          "start": 49187807,
          "end": 49200218,
          "strand": "-",
          "slug": "syp"
        },
        {
          "symbol": "CACNA1F",
          "ensemblId": "ENSG00000102001",
          "biotype": "protein_coding",
          "start": 49205063,
          "end": 49233371,
          "strand": "-",
          "slug": "cacna1f"
        },
        {
          "symbol": "FOXP3",
          "ensemblId": "ENSG00000049768",
          "biotype": "protein_coding",
          "start": 49250436,
          "end": 49264800,
          "strand": "-",
          "slug": "foxp3"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000290184",
          "biotype": "protein_coding",
          "start": 49258343,
          "end": 49270477,
          "strand": "-"
        },
        {
          "symbol": "PPP1R3F",
          "ensemblId": "ENSG00000049769",
          "biotype": "protein_coding",
          "start": 49269771,
          "end": 49301468,
          "strand": "+",
          "slug": "ppp1r3f"
        },
        {
          "symbol": "GAGE10",
          "ensemblId": "ENSG00000215274",
          "biotype": "protein_coding",
          "start": 49303645,
          "end": 49319844,
          "strand": "+",
          "slug": "gage10"
        },
        {
          "symbol": "GAGE12J",
          "ensemblId": "ENSG00000224659",
          "biotype": "protein_coding",
          "start": 49322037,
          "end": 49329387,
          "strand": "+",
          "slug": "gage12j"
        },
        {
          "symbol": "GAGE13",
          "ensemblId": "ENSG00000274274",
          "biotype": "protein_coding",
          "start": 49331575,
          "end": 49338952,
          "strand": "+",
          "slug": "gage13"
        },
        {
          "symbol": "GAGE2E",
          "ensemblId": "ENSG00000275113",
          "biotype": "protein_coding",
          "start": 49341192,
          "end": 49345922,
          "strand": "+",
          "slug": "gage2e"
        },
        {
          "symbol": "GAGE12B",
          "ensemblId": "ENSG00000236737",
          "biotype": "protein_coding",
          "start": 49529869,
          "end": 49529985,
          "strand": "+",
          "slug": "gage12b"
        },
        {
          "symbol": "GAGE12C",
          "ensemblId": "ENSG00000237671",
          "biotype": "protein_coding",
          "start": 49532177,
          "end": 49539541,
          "strand": "+",
          "slug": "gage12c"
        },
        {
          "symbol": "GAGE12D",
          "ensemblId": "ENSG00000227488",
          "biotype": "protein_coding",
          "start": 49541733,
          "end": 49549097,
          "strand": "+",
          "slug": "gage12d"
        },
        {
          "symbol": "GAGE12E",
          "ensemblId": "ENSG00000216649",
          "biotype": "protein_coding",
          "start": 49551289,
          "end": 49558645,
          "strand": "+",
          "slug": "gage12e"
        },
        {
          "symbol": "GAGE12F",
          "ensemblId": "ENSG00000236362",
          "biotype": "protein_coding",
          "start": 49560842,
          "end": 49568209,
          "strand": "+",
          "slug": "gage12f"
        },
        {
          "symbol": "GAGE12G",
          "ensemblId": "ENSG00000215269",
          "biotype": "protein_coding",
          "start": 49570400,
          "end": 49577757,
          "strand": "+",
          "slug": "gage12g"
        },
        {
          "symbol": "GAGE12H",
          "ensemblId": "ENSG00000224902",
          "biotype": "protein_coding",
          "start": 49579945,
          "end": 49587304,
          "strand": "+",
          "slug": "gage12h"
        },
        {
          "symbol": "GAGE2A",
          "ensemblId": "ENSG00000189064",
          "biotype": "protein_coding",
          "start": 49589476,
          "end": 49596834,
          "strand": "+",
          "slug": "gage2a"
        },
        {
          "symbol": "GAGE1",
          "ensemblId": "ENSG00000205777",
          "biotype": "protein_coding",
          "start": 49599020,
          "end": 49608538,
          "strand": "+",
          "slug": "gage1"
        },
        {
          "symbol": "PAGE1",
          "ensemblId": "ENSG00000068985",
          "biotype": "protein_coding",
          "start": 49687445,
          "end": 49696024,
          "strand": "-",
          "slug": "page1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "ectopic-anus",
        "name": "Abnormal anus position",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ectopic-anus"
      },
      {
        "slug": "abnormal-cranial-suture-fontanelle-morphology",
        "name": "Abnormal cranial suture/fontanelle morphology",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-cranial-suture-fontanelle-morphology"
      },
      {
        "slug": "abnormal-mitral-valve-morphology",
        "name": "Abnormal mitral valve morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-mitral-valve-morphology"
      },
      {
        "slug": "abnormal-speech-pattern",
        "name": "Abnormal speech pattern",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-speech-pattern"
      },
      {
        "slug": "abnormal-tricuspid-valve-morphology",
        "name": "Abnormal tricuspid valve morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-tricuspid-valve-morphology"
      },
      {
        "slug": "abnormality-of-neuronal-migration",
        "name": "Abnormality of neuronal migration",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-neuronal-migration"
      },
      {
        "slug": "abnormal-hip-bone-morphology",
        "name": "Abnormality of the hip bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-hip-bone-morphology"
      },
      {
        "slug": "anal-atresia",
        "name": "Absent anus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anal-atresia"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-cerebellum",
        "name": "Absent/small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-cerebellum"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-nipples",
        "name": "Absent/small nipples",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-nipples"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "convex-nasal-ridge",
        "name": "Beaked nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/convex-nasal-ridge"
      },
      {
        "slug": "macrocephaly",
        "name": "Big calvaria",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/macrocephaly"
      },
      {
        "slug": "chorioretinal-coloboma",
        "name": "Birth defect that causes a hole in the innermost layer at the back of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chorioretinal-coloboma"
      },
      {
        "slug": "broad-hallux",
        "name": "Broad big toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/broad-hallux"
      },
      {
        "slug": "broad-forehead",
        "name": "Broad forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/broad-forehead"
      },
      {
        "slug": "broad-neck",
        "name": "Broad neck",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/broad-neck"
      },
      {
        "slug": "iris-coloboma",
        "name": "Cat eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/iris-coloboma"
      },
      {
        "slug": "orofacial-cleft",
        "name": "Cleft of the mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orofacial-cleft"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "dandy-walker-malformation",
        "name": "Dandy-Walker malformation",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/dandy-walker-malformation"
      },
      {
        "slug": "delayed-ability-to-walk",
        "name": "Delayed ability to walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-ability-to-walk"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "downslanted-palpebral-fissures",
        "name": "Downward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/downslanted-palpebral-fissures"
      },
      {
        "slug": "hand-polydactyly",
        "name": "Extra finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hand-polydactyly"
      },
      {
        "slug": "facial-hemangioma",
        "name": "Facial hemangioma",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/facial-hemangioma"
      },
      {
        "slug": "feeding-difficulties-in-infancy",
        "name": "Feeding difficulties in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/feeding-difficulties-in-infancy"
      },
      {
        "slug": "finger-syndactyly",
        "name": "Finger syndactyly",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/finger-syndactyly"
      },
      {
        "slug": "arachnoid-cyst",
        "name": "Fluid-filled sac located in membrane surrounding brain or spinal cord",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arachnoid-cyst"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "glaucoma",
        "name": "Glaucoma",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/glaucoma"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "postnatal-growth-retardation",
        "name": "Growth delay as children",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/postnatal-growth-retardation"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "high-narrow-palate",
        "name": "High, narrow palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/high-narrow-palate"
      },
      {
        "slug": "atrioventricular-canal-defect",
        "name": "Hole in center of heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atrioventricular-canal-defect"
      },
      {
        "slug": "ventricular-septal-defect",
        "name": "Hole in heart wall separating two lower heart chambers",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventricular-septal-defect"
      },
      {
        "slug": "kyphosis",
        "name": "Hunched back",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/kyphosis"
      },
      {
        "slug": "hydronephrosis",
        "name": "Hydronephrosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hydronephrosis"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "inguinal-hernia",
        "name": "Inguinal hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/inguinal-hernia"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "intestinal-malrotation",
        "name": "Intestinal malrotation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intestinal-malrotation"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "low-posterior-hairline",
        "name": "Low hairline at back of neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/low-posterior-hairline"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "hemivertebrae",
        "name": "Missing part of vertebrae",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hemivertebrae"
      },
      {
        "slug": "missing-ribs",
        "name": "Missing ribs",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/missing-ribs"
      },
      {
        "slug": "aortic-valve-stenosis",
        "name": "Narrowing of aortic valve",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aortic-valve-stenosis"
      },
      {
        "slug": "pulmonic-stenosis",
        "name": "Narrowing of pulmonic valve",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulmonic-stenosis"
      },
      {
        "slug": "single-umbilical-artery",
        "name": "Only one artery in umbilical cord instead of two",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/single-umbilical-artery"
      },
      {
        "slug": "optic-atrophy",
        "name": "Optic atrophy",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/optic-atrophy"
      },
      {
        "slug": "overlapping-toe",
        "name": "Overlapping toe",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/overlapping-toe"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "camptodactyly-of-finger",
        "name": "Permanent flexion of the finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/camptodactyly-of-finger"
      },
      {
        "slug": "camptodactyly",
        "name": "Permanent flexion of the finger or toe",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/camptodactyly"
      },
      {
        "slug": "poor-speech",
        "name": "Poor speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/poor-speech"
      },
      {
        "slug": "prominent-occiput",
        "name": "Prominent back of the head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/prominent-occiput"
      },
      {
        "slug": "prominent-fingertip-pads",
        "name": "Prominent fingertip pads",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prominent-fingertip-pads"
      },
      {
        "slug": "protruding-tongue",
        "name": "Protruding tongue",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/protruding-tongue"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      },
      {
        "slug": "relative-macrocephaly",
        "name": "Relatively large head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/relative-macrocephaly"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "brachydactyly",
        "name": "Short fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/brachydactyly"
      },
      {
        "slug": "short-neck",
        "name": "Short neck",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-neck"
      },
      {
        "slug": "short-nose",
        "name": "Short nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-nose"
      },
      {
        "slug": "short-distal-phalanx-of-finger",
        "name": "Short outermost finger bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/short-distal-phalanx-of-finger"
      },
      {
        "slug": "short-philtrum",
        "name": "Short philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-philtrum"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "preauricular-skin-tag",
        "name": "Skin tag in front of the ear",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/preauricular-skin-tag"
      },
      {
        "slug": "adrenal-hypoplasia",
        "name": "Small adrenal glands",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/adrenal-hypoplasia"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "hypoplastic-fingernail",
        "name": "Small fingernail",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplastic-fingernail"
      },
      {
        "slug": "tetralogy-of-fallot",
        "name": "Tetralogy of Fallot",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/tetralogy-of-fallot"
      },
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydrocephalus"
      },
      {
        "slug": "hypoplastic-left-ventricle",
        "name": "Underdeveloped left heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplastic-left-ventricle"
      },
      {
        "slug": "pulmonary-artery-hypoplasia",
        "name": "Underdeveloped lung artery",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-artery-hypoplasia"
      },
      {
        "slug": "hypoplasia-of-penis",
        "name": "Underdeveloped penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-penis"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "upslanted-palpebral-fissure",
        "name": "Upward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/upslanted-palpebral-fissure"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      },
      {
        "slug": "syndactyly",
        "name": "Webbed fingers or toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/syndactyly"
      },
      {
        "slug": "wide-nasal-bridge",
        "name": "Wide nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/wide-nasal-bridge"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypertelorism"
      },
      {
        "slug": "wide-anterior-fontanel",
        "name": "Wider-than-typical soft spot of skull",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/wide-anterior-fontanel"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}