{
  "url": "https://dantelabs.com/traits/very-low-visual-acuity",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "very-low-visual-acuity",
    "id": "HP:0032122",
    "name": "Very low visual acuity",
    "definition": "A reduction in visual acuity with best corrected visual acuity between 1.40 (20/500) and 1.89 logMAR (up to roughly 20/1590).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "reduced-visual-acuity",
        "name": "Decreased clarity of vision",
        "url": "https://dantelabs.com/traits/reduced-visual-acuity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "rpgrip1",
        "symbol": "RPGRIP1",
        "hgnc": "HGNC:13436",
        "name": "RPGR interacting protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rpgrip1"
      },
      {
        "slug": "col8a2",
        "symbol": "COL8A2",
        "hgnc": "HGNC:2216",
        "name": "collagen type VIII alpha 2 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col8a2"
      },
      {
        "slug": "grhl2",
        "symbol": "GRHL2",
        "hgnc": "HGNC:2799",
        "name": "grainyhead like transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhl2"
      },
      {
        "slug": "ovol2",
        "symbol": "OVOL2",
        "hgnc": "HGNC:15804",
        "name": "ovo like zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ovol2"
      },
      {
        "slug": "vsx1",
        "symbol": "VSX1",
        "hgnc": "HGNC:12723",
        "name": "visual system homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vsx1"
      },
      {
        "slug": "zeb1",
        "symbol": "ZEB1",
        "hgnc": "HGNC:11642",
        "name": "zinc finger E-box binding homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zeb1"
      }
    ]
  }
}