{
  "url": "https://dantelabs.com/traits/uric-acid-nephrolithiasis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "uric-acid-nephrolithiasis",
    "id": "HP:0000791",
    "name": "Uric acid stones",
    "label": "Uric acid nephrolithiasis",
    "definition": "The presence of uric acid-containing calculi (stones) in the kidneys.",
    "synonyms": [
      "Uric acid urolithiasis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "url": "https://dantelabs.com/traits/kidney-stone"
      }
    ],
    "narrower": [
      {
        "slug": "uric-acid-urolithiasis-independent-of-gout",
        "name": "Uric acid urolithiasis independent of gout",
        "genes": 2,
        "url": "https://dantelabs.com/traits/uric-acid-urolithiasis-independent-of-gout"
      }
    ],
    "genes": [
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "aprt",
        "symbol": "APRT",
        "hgnc": "HGNC:626",
        "name": "adenine phosphoribosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aprt"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "hprt1",
        "symbol": "HPRT1",
        "hgnc": "HGNC:5157",
        "name": "hypoxanthine phosphoribosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hprt1"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      }
    ]
  }
}