{
  "url": "https://dantelabs.com/traits/serous-retinal-detachment",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "serous-retinal-detachment",
    "id": "HP:0012231",
    "name": "Serous retinal detachment",
    "definition": "A type of retinal detachment such that fluid is present in the subretinal space and separate the neurosensory retina from the retinal pigment epithelium. It is not associated with a full-thickness break nor a tractional component. Due to breakdown of outer blood-retina barrier or increased exudation from abnormal vasculature or defective outflow.",
    "synonyms": [
      "Exudative retinal detachment",
      "Non-rhegmatogenous retinal detachment"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "retinal-detachment",
        "name": "Retinal detachment",
        "url": "https://dantelabs.com/traits/retinal-detachment"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrp5"
      },
      {
        "slug": "max",
        "symbol": "MAX",
        "hgnc": "HGNC:6913",
        "name": "MYC associated transcriptional regulator X",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/max"
      },
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "dnmt3b",
        "symbol": "DNMT3B",
        "hgnc": "HGNC:2979",
        "name": "DNA methyltransferase 3 beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3b"
      },
      {
        "slug": "dux4",
        "symbol": "DUX4",
        "hgnc": "HGNC:50800",
        "name": "double homeobox 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dux4"
      },
      {
        "slug": "dux4l1",
        "symbol": "DUX4L1",
        "hgnc": "HGNC:3082",
        "name": "double homeobox 4 like 1 (pseudogene)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dux4l1"
      },
      {
        "slug": "efemp1",
        "symbol": "EFEMP1",
        "hgnc": "HGNC:3218",
        "name": "EGF-like fibulin extracellular matrix protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp1"
      },
      {
        "slug": "frg1",
        "symbol": "FRG1",
        "hgnc": "HGNC:3954",
        "name": "FSHD region gene 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/frg1"
      },
      {
        "slug": "smchd1",
        "symbol": "SMCHD1",
        "hgnc": "HGNC:29090",
        "name": "structural maintenance of chromosomes flexible hinge domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smchd1"
      },
      {
        "slug": "ctc1",
        "symbol": "CTC1",
        "hgnc": "HGNC:26169",
        "name": "CST telomere replication complex component 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctc1"
      },
      {
        "slug": "igfbp7",
        "symbol": "IGFBP7",
        "hgnc": "HGNC:5476",
        "name": "insulin like growth factor binding protein 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igfbp7"
      }
    ]
  }
}