{
  "url": "https://dantelabs.com/traits/reduced-hemoglobin-a",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "reduced-hemoglobin-a",
    "id": "HP:0011905",
    "name": "Reduced hemoglobin A",
    "definition": "Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.",
    "synonyms": [
      "Reduced haemoglobin A",
      "Reduced HbA"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/hbb"
      }
    ]
  }
}