{
  "url": "https://dantelabs.com/traits/prolonged-bleeding-after-surgery",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "prolonged-bleeding-after-surgery",
    "id": "HP:0004846",
    "name": "Prolonged bleeding after surgery",
    "definition": "Bleeding that persists longer than the normal time following a surgical procedure.",
    "synonyms": [
      "Excessive bleeding during surgery",
      "Protracted bleeding after surgery"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "prolonged-bleeding-following-procedure",
        "name": "Prolonged bleeding following procedure",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-following-procedure"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "ano6",
        "symbol": "ANO6",
        "hgnc": "HGNC:25240",
        "name": "anoctamin 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano6"
      },
      {
        "slug": "serpine1",
        "symbol": "SERPINE1",
        "hgnc": "HGNC:8583",
        "name": "serpin family E member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpine1"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "vwf",
        "symbol": "VWF",
        "hgnc": "HGNC:12726",
        "name": "von Willebrand factor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vwf"
      },
      {
        "slug": "actn1",
        "symbol": "ACTN1",
        "hgnc": "HGNC:163",
        "name": "actinin alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actn1"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "gfi1b",
        "symbol": "GFI1B",
        "hgnc": "HGNC:4238",
        "name": "growth factor independent 1B transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfi1b"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "mcfd2",
        "symbol": "MCFD2",
        "hgnc": "HGNC:18451",
        "name": "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcfd2"
      },
      {
        "slug": "tpm4",
        "symbol": "TPM4",
        "hgnc": "HGNC:12013",
        "name": "tropomyosin 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tpm4"
      },
      {
        "slug": "trpm7",
        "symbol": "TRPM7",
        "hgnc": "HGNC:17994",
        "name": "transient receptor potential cation channel subfamily M member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm7"
      },
      {
        "slug": "tuba8",
        "symbol": "TUBA8",
        "hgnc": "HGNC:12410",
        "name": "tubulin alpha 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba8"
      },
      {
        "slug": "tubb1",
        "symbol": "TUBB1",
        "hgnc": "HGNC:16257",
        "name": "tubulin beta 1 class VI",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb1"
      },
      {
        "slug": "p2ry12",
        "symbol": "P2RY12",
        "hgnc": "HGNC:18124",
        "name": "purinergic receptor P2Y12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/p2ry12"
      }
    ]
  }
}