{
  "url": "https://dantelabs.com/traits/oroticaciduria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "oroticaciduria",
    "id": "HP:0003218",
    "name": "High urine orotic acid levels",
    "label": "Oroticaciduria",
    "definition": "An increased concentration of orotic acid in the urine.",
    "synonyms": [
      "Increased urinary orotic acid concentration"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-urine-carboxylic-acid-level",
        "name": "Abnormal urine carboxylic acid level",
        "url": "https://dantelabs.com/traits/abnormal-urine-carboxylic-acid-level"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ass1",
        "symbol": "ASS1",
        "hgnc": "HGNC:758",
        "name": "argininosuccinate synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ass1"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "otc",
        "symbol": "OTC",
        "hgnc": "HGNC:8512",
        "name": "ornithine transcarbamylase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/otc"
      },
      {
        "slug": "umps",
        "symbol": "UMPS",
        "hgnc": "HGNC:12563",
        "name": "uridine monophosphate synthetase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/umps"
      },
      {
        "slug": "slc25a15",
        "symbol": "SLC25A15",
        "hgnc": "HGNC:10985",
        "name": "solute carrier family 25 member 15",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a15"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "arg1",
        "symbol": "ARG1",
        "hgnc": "HGNC:663",
        "name": "arginase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arg1"
      }
    ]
  }
}