{
  "url": "https://dantelabs.com/traits/myelopathy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "myelopathy",
    "id": "HP:0002196",
    "name": "Myelopathy",
    "definition": "Myelopathy is an descriptive term, referring to pathology leading to a neurologic deficit related to the spinal cord. The clinical diagnosis of myelopathy requires a detailed history and physical examination to define the clinical syndrome. Neuroimaging is indicated in most instances of new-onset myelopathy. It is indicated also when the worsening of a myelopathy is unexplained.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-spinal-cord-morphology",
        "name": "Abnormality of the spinal cord",
        "url": "https://dantelabs.com/traits/abnormal-spinal-cord-morphology"
      },
      {
        "slug": "closed-neural-tube-defect",
        "name": "Closed neural tube defect",
        "url": "https://dantelabs.com/traits/closed-neural-tube-defect"
      }
    ],
    "narrower": [
      {
        "slug": "cervical-myelopathy",
        "name": "Cervical myelopathy",
        "genes": 8,
        "url": "https://dantelabs.com/traits/cervical-myelopathy"
      }
    ],
    "genes": [
      {
        "slug": "naxe",
        "symbol": "NAXE",
        "hgnc": "HGNC:18453",
        "name": "NAD(P)HX epimerase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/naxe"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "dkk1",
        "symbol": "DKK1",
        "hgnc": "HGNC:2891",
        "name": "dickkopf Wnt signaling pathway inhibitor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkk1"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "btd",
        "symbol": "BTD",
        "hgnc": "HGNC:1122",
        "name": "biotinidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btd"
      },
      {
        "slug": "rasa1",
        "symbol": "RASA1",
        "hgnc": "HGNC:9871",
        "name": "RAS p21 protein activator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasa1"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      },
      {
        "slug": "gnptab",
        "symbol": "GNPTAB",
        "hgnc": "HGNC:29670",
        "name": "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptab"
      }
    ]
  }
}