{
  "url": "https://dantelabs.com/traits/mitten-deformity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "mitten-deformity",
    "id": "HP:0004057",
    "name": "Mitten deformity",
    "definition": "Fusion of the hands and feet by a thin membrane of skin (scarring) seen in forms of dystrophic epidermolysis bullosa and leading to a \"mitten\" hand deformity.",
    "synonyms": [
      "Pseudosyndactyly"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hand-morphology",
        "name": "Abnormal shape of hand",
        "url": "https://dantelabs.com/traits/abnormal-hand-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      }
    ]
  }
}