{
  "url": "https://dantelabs.com/traits/malignant-hyperthermia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "malignant-hyperthermia",
    "id": "HP:0002047",
    "name": "Malignant hyperthermia",
    "definition": "Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-temperature-regulation",
        "name": "Abnormality of temperature regulation",
        "url": "https://dantelabs.com/traits/abnormality-of-temperature-regulation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atp2a1",
        "symbol": "ATP2A1",
        "hgnc": "HGNC:811",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a1"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "clcf1",
        "symbol": "CLCF1",
        "hgnc": "HGNC:17412",
        "name": "cardiotrophin like cytokine factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcf1"
      },
      {
        "slug": "crlf1",
        "symbol": "CRLF1",
        "hgnc": "HGNC:2364",
        "name": "cytokine receptor like factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crlf1"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "hgnc": "HGNC:5959",
        "name": "elongator acetyltransferase complex subunit 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp1"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "very-frequent",
        "diseases": 8,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "trappc9",
        "symbol": "TRAPPC9",
        "hgnc": "HGNC:30832",
        "name": "trafficking protein particle complex subunit 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc9"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "myh3",
        "symbol": "MYH3",
        "hgnc": "HGNC:7573",
        "name": "myosin heavy chain 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myh3"
      },
      {
        "slug": "nalcn",
        "symbol": "NALCN",
        "hgnc": "HGNC:19082",
        "name": "sodium leak channel, non-selective",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nalcn"
      },
      {
        "slug": "stac3",
        "symbol": "STAC3",
        "hgnc": "HGNC:28423",
        "name": "SH3 and cysteine rich domain 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stac3"
      },
      {
        "slug": "abca12",
        "symbol": "ABCA12",
        "hgnc": "HGNC:14637",
        "name": "ATP binding cassette subfamily A member 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca12"
      },
      {
        "slug": "edar",
        "symbol": "EDAR",
        "hgnc": "HGNC:2895",
        "name": "ectodysplasin A receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edar"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "hspg2",
        "symbol": "HSPG2",
        "hgnc": "HGNC:5273",
        "name": "heparan sulfate proteoglycan 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hspg2"
      },
      {
        "slug": "kdf1",
        "symbol": "KDF1",
        "hgnc": "HGNC:26624",
        "name": "keratinocyte differentiation factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdf1"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "pgm1",
        "symbol": "PGM1",
        "hgnc": "HGNC:8905",
        "name": "phosphoglucomutase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm1"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "traf6",
        "symbol": "TRAF6",
        "hgnc": "HGNC:12036",
        "name": "TNF receptor associated factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf6"
      },
      {
        "slug": "bin1",
        "symbol": "BIN1",
        "hgnc": "HGNC:1052",
        "name": "bridging integrator 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bin1"
      },
      {
        "slug": "dnm2",
        "symbol": "DNM2",
        "hgnc": "HGNC:2974",
        "name": "dynamin 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm2"
      },
      {
        "slug": "mtmr14",
        "symbol": "MTMR14",
        "hgnc": "HGNC:26190",
        "name": "myotubularin related protein 14",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtmr14"
      },
      {
        "slug": "myf6",
        "symbol": "MYF6",
        "hgnc": "HGNC:7566",
        "name": "myogenic factor 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myf6"
      },
      {
        "slug": "chrna1",
        "symbol": "CHRNA1",
        "hgnc": "HGNC:1955",
        "name": "cholinergic receptor nicotinic alpha 1 subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna1"
      },
      {
        "slug": "chrnd",
        "symbol": "CHRND",
        "hgnc": "HGNC:1965",
        "name": "cholinergic receptor nicotinic delta subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnd"
      },
      {
        "slug": "chrng",
        "symbol": "CHRNG",
        "hgnc": "HGNC:1967",
        "name": "cholinergic receptor nicotinic gamma subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrng"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      }
    ]
  }
}