{
  "url": "https://dantelabs.com/traits/long-hallux",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "long-hallux",
    "id": "HP:0001847",
    "name": "Long big toe",
    "label": "Long hallux",
    "definition": "Increased length of the big toe.",
    "synonyms": [
      "Increased length of the hallux",
      "Large halluces",
      "Long halluces"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hallux-morphology",
        "name": "Abnormality of the big toe",
        "url": "https://dantelabs.com/traits/abnormal-hallux-morphology"
      },
      {
        "slug": "long-toe",
        "name": "Long toe",
        "url": "https://dantelabs.com/traits/long-toe"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "kcnh1",
        "symbol": "KCNH1",
        "hgnc": "HGNC:6250",
        "name": "potassium voltage-gated channel subfamily H member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnh1"
      },
      {
        "slug": "npr2",
        "symbol": "NPR2",
        "hgnc": "HGNC:7944",
        "name": "natriuretic peptide receptor 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/npr2"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "scarf2",
        "symbol": "SCARF2",
        "hgnc": "HGNC:19869",
        "name": "scavenger receptor class F member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarf2"
      },
      {
        "slug": "sms",
        "symbol": "SMS",
        "hgnc": "HGNC:11123",
        "name": "spermine synthase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sms"
      },
      {
        "slug": "znf668",
        "symbol": "ZNF668",
        "hgnc": "HGNC:25821",
        "name": "zinc finger protein 668",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf668"
      },
      {
        "slug": "gne",
        "symbol": "GNE",
        "hgnc": "HGNC:23657",
        "name": "glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gne"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "kat6b",
        "symbol": "KAT6B",
        "hgnc": "HGNC:17582",
        "name": "lysine acetyltransferase 6B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kat6b"
      },
      {
        "slug": "kcnn3",
        "symbol": "KCNN3",
        "hgnc": "HGNC:6292",
        "name": "potassium calcium-activated channel subfamily N member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn3"
      },
      {
        "slug": "nkx3-2",
        "symbol": "NKX3-2",
        "hgnc": "HGNC:951",
        "name": "NK3 homeobox 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx3-2"
      },
      {
        "slug": "npr3",
        "symbol": "NPR3",
        "hgnc": "HGNC:7945",
        "name": "natriuretic peptide receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npr3"
      },
      {
        "slug": "polr3gl",
        "symbol": "POLR3GL",
        "hgnc": "HGNC:28466",
        "name": "RNA polymerase III subunit GL",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3gl"
      },
      {
        "slug": "dpm1",
        "symbol": "DPM1",
        "hgnc": "HGNC:3005",
        "name": "dolichyl-phosphate mannosyltransferase subunit 1, catalytic",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm1"
      },
      {
        "slug": "fam20c",
        "symbol": "FAM20C",
        "hgnc": "HGNC:22140",
        "name": "FAM20C golgi associated secretory pathway kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam20c"
      },
      {
        "slug": "fibp",
        "symbol": "FIBP",
        "hgnc": "HGNC:3705",
        "name": "FGF1 intracellular binding protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fibp"
      },
      {
        "slug": "gnai1",
        "symbol": "GNAI1",
        "hgnc": "HGNC:4384",
        "name": "G protein subunit alpha i1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnai1"
      },
      {
        "slug": "kmt2a",
        "symbol": "KMT2A",
        "hgnc": "HGNC:7132",
        "name": "lysine methyltransferase 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2a"
      },
      {
        "slug": "sox5",
        "symbol": "SOX5",
        "hgnc": "HGNC:11201",
        "name": "SRY-box transcription factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox5"
      },
      {
        "slug": "traf7",
        "symbol": "TRAF7",
        "hgnc": "HGNC:20456",
        "name": "TNF receptor associated factor 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf7"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      }
    ]
  }
}