{
  "url": "https://dantelabs.com/traits/limb-dysmetria",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "limb-dysmetria",
    "id": "HP:0002406",
    "name": "Uncoordinated limb movement",
    "label": "Limb dysmetria",
    "definition": "A type of dysmetria involving the limbs.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "dysmetria",
        "name": "Lack of coordination of movement",
        "url": "https://dantelabs.com/traits/dysmetria"
      }
    ],
    "narrower": [
      {
        "slug": "lower-limb-dysmetria",
        "name": "Lower limb dysmetria",
        "genes": 1,
        "url": "https://dantelabs.com/traits/lower-limb-dysmetria"
      },
      {
        "slug": "upper-limb-dysmetria",
        "name": "Upper limb dysmetria",
        "genes": 1,
        "url": "https://dantelabs.com/traits/upper-limb-dysmetria"
      }
    ],
    "genes": [
      {
        "slug": "itpr1",
        "symbol": "ITPR1",
        "hgnc": "HGNC:6180",
        "name": "inositol 1,4,5-trisphosphate receptor type 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itpr1"
      },
      {
        "slug": "dab1",
        "symbol": "DAB1",
        "hgnc": "HGNC:2661",
        "name": "DAB adaptor protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dab1"
      },
      {
        "slug": "grm1",
        "symbol": "GRM1",
        "hgnc": "HGNC:4593",
        "name": "glutamate metabotropic receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grm1"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "ppp2r2b",
        "symbol": "PPP2R2B",
        "hgnc": "HGNC:9305",
        "name": "protein phosphatase 2 regulatory subunit Bbeta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r2b"
      },
      {
        "slug": "washc5",
        "symbol": "WASHC5",
        "hgnc": "HGNC:28984",
        "name": "WASH complex subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/washc5"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "rnaseh1",
        "symbol": "RNASEH1",
        "hgnc": "HGNC:18466",
        "name": "ribonuclease H1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "gba2",
        "symbol": "GBA2",
        "hgnc": "HGNC:18986",
        "name": "glucosylceramidase beta 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba2"
      },
      {
        "slug": "jam2",
        "symbol": "JAM2",
        "hgnc": "HGNC:14686",
        "name": "junctional adhesion molecule 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jam2"
      },
      {
        "slug": "kcnc3",
        "symbol": "KCNC3",
        "hgnc": "HGNC:6235",
        "name": "potassium voltage-gated channel subfamily C member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnc3"
      },
      {
        "slug": "myorg",
        "symbol": "MYORG",
        "hgnc": "HGNC:19918",
        "name": "myogenesis regulating glycosidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myorg"
      },
      {
        "slug": "naa60",
        "symbol": "NAA60",
        "hgnc": "HGNC:25875",
        "name": "N-alpha-acetyltransferase 60, NatF catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa60"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "slc20a2",
        "symbol": "SLC20A2",
        "hgnc": "HGNC:10947",
        "name": "solute carrier family 20 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc20a2"
      },
      {
        "slug": "xpr1",
        "symbol": "XPR1",
        "hgnc": "HGNC:12827",
        "name": "xenotropic and polytropic retrovirus receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpr1"
      },
      {
        "slug": "zfhx3",
        "symbol": "ZFHX3",
        "hgnc": "HGNC:777",
        "name": "zinc finger homeobox 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfhx3"
      }
    ]
  }
}