{
  "url": "https://dantelabs.com/traits/lichenification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "lichenification",
    "id": "HP:0100725",
    "name": "Lichenification",
    "definition": "Thickening and hardening of the epidermis seen with exaggeration of normal skin lines.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology",
        "name": "Abnormal skin structure",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "flexural-lichenification",
        "name": "Flexural lichenification",
        "genes": 2,
        "url": "https://dantelabs.com/traits/flexural-lichenification"
      }
    ],
    "genes": [
      {
        "slug": "osmr",
        "symbol": "OSMR",
        "hgnc": "HGNC:8507",
        "name": "oncostatin M receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/osmr"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "hla-dra",
        "symbol": "HLA-DRA",
        "hgnc": "HGNC:4947",
        "name": "major histocompatibility complex, class II, DR alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dra"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "card14",
        "symbol": "CARD14",
        "hgnc": "HGNC:16446",
        "name": "caspase recruitment domain family member 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card14"
      },
      {
        "slug": "flt4",
        "symbol": "FLT4",
        "hgnc": "HGNC:3767",
        "name": "fms related receptor tyrosine kinase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt4"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "csta",
        "symbol": "CSTA",
        "hgnc": "HGNC:2481",
        "name": "cystatin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csta"
      }
    ]
  }
}