{
  "url": "https://dantelabs.com/traits/laryngeal-cleft",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "laryngeal-cleft",
    "id": "HP:0008751",
    "name": "Laryngeal cleft",
    "definition": "Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esophagus.",
    "synonyms": [
      "Laryngotracheal cleft",
      "Laryngotracheoesophageal cleft i"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-larynx-morphology",
        "name": "Abnormal larynx morphology",
        "url": "https://dantelabs.com/traits/abnormal-larynx-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "mid1",
        "symbol": "MID1",
        "hgnc": "HGNC:7095",
        "name": "midline 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mid1"
      },
      {
        "slug": "phip",
        "symbol": "PHIP",
        "hgnc": "HGNC:15673",
        "name": "PHIP subunit of CUL4-Ring ligase complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phip"
      },
      {
        "slug": "capn15",
        "symbol": "CAPN15",
        "hgnc": "HGNC:11182",
        "name": "calpain 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn15"
      },
      {
        "slug": "edn1",
        "symbol": "EDN1",
        "hgnc": "HGNC:3176",
        "name": "endothelin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edn1"
      },
      {
        "slug": "fbxw7",
        "symbol": "FBXW7",
        "hgnc": "HGNC:16712",
        "name": "F-box and WD repeat domain containing 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxw7"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      }
    ]
  }
}