{
  "url": "https://dantelabs.com/traits/ivory-epiphyses",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ivory-epiphyses",
    "id": "HP:0010583",
    "name": "Increased bone density in end part of bone",
    "label": "Ivory epiphyses",
    "definition": "Sclerosis of the epiphyses, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.",
    "synonyms": [
      "Epiphyseal sclerosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-epiphysis-morphology",
        "name": "Abnormal shape of end part of bone",
        "url": "https://dantelabs.com/traits/abnormal-epiphysis-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "ivory-epiphyses-of-the-phalanges-of-the-hand",
        "name": "Increased bone density of end part of the hand bones",
        "genes": 4,
        "url": "https://dantelabs.com/traits/ivory-epiphyses-of-the-phalanges-of-the-hand"
      },
      {
        "slug": "ivory-epiphyses-of-the-toes",
        "name": "Increased bone density of end part of the toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ivory-epiphyses-of-the-toes"
      }
    ],
    "genes": [
      {
        "slug": "pcyt1a",
        "symbol": "PCYT1A",
        "hgnc": "HGNC:8754",
        "name": "phosphate cytidylyltransferase 1A, choline",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcyt1a"
      },
      {
        "slug": "pcnt",
        "symbol": "PCNT",
        "hgnc": "HGNC:16068",
        "name": "pericentrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcnt"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      }
    ]
  }
}