{
  "url": "https://dantelabs.com/traits/increased-circulating-androgen-concentration",
  "trait": {
    "bundleId": "2026.10.21-777c9289",
    "release": "2026-09-01",
    "slug": "increased-circulating-androgen-concentration",
    "id": "HP:0030348",
    "name": "Increased circulating androgen concentration",
    "definition": "An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.",
    "synonyms": [
      "Hyperandrogenemia",
      "Increased circulating androgen level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-androgen-level",
        "name": "Abnormal circulating androgen level",
        "url": "https://dantelabs.com/traits/abnormal-circulating-androgen-level"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-androstenedione-concentration",
        "name": "Increased circulating androstenedione concentration",
        "genes": 11,
        "url": "https://dantelabs.com/traits/increased-circulating-androstenedione-concentration"
      },
      {
        "slug": "increased-serum-testosterone-level",
        "name": "Increased testosterone",
        "genes": 11,
        "url": "https://dantelabs.com/traits/increased-serum-testosterone-level"
      }
    ],
    "genes": [
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "cyp11b1",
        "symbol": "CYP11B1",
        "hgnc": "HGNC:2591",
        "name": "cytochrome P450 family 11 subfamily B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp11b1"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "h6pd",
        "symbol": "H6PD",
        "hgnc": "HGNC:4795",
        "name": "hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h6pd"
      },
      {
        "slug": "hsd11b1",
        "symbol": "HSD11B1",
        "hgnc": "HGNC:5208",
        "name": "hydroxysteroid 11-beta dehydrogenase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd11b1"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "znrf3",
        "symbol": "ZNRF3",
        "hgnc": "HGNC:18126",
        "name": "zinc and ring finger 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znrf3"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "alg6",
        "symbol": "ALG6",
        "hgnc": "HGNC:23157",
        "name": "ALG6 alpha-1,3-glucosyltransferase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg6"
      }
    ]
  }
}