{
  "url": "https://dantelabs.com/traits/hypokalemia",
  "trait": {
    "bundleId": "2026.10.21-311f020e",
    "release": "2026-09-01",
    "slug": "hypokalemia",
    "id": "HP:0002900",
    "name": "Low blood potassium levels",
    "label": "Hypokalemia",
    "definition": "The concentration of potassium(1+) in the blood circulation is below the lower limit of normal.",
    "synonyms": [
      "Decreased potassium(1+) concentration",
      "Decreased potassium(1+) level",
      "Decreased potassium(1+) level in blood",
      "Reduced potassium(1+) concentration",
      "Reduced potassium(1+) level",
      "Reduced potassium(1+) level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-potassium-concentration",
        "name": "Abnormal circulating potassium concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-potassium-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "episodic-hypokalemia",
        "name": "Recurrent low potassium",
        "genes": 6,
        "url": "https://dantelabs.com/traits/episodic-hypokalemia"
      }
    ],
    "genes": [
      {
        "slug": "atp1a1",
        "symbol": "ATP1A1",
        "hgnc": "HGNC:799",
        "name": "ATPase Na+/K+ transporting subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a1"
      },
      {
        "slug": "bsnd",
        "symbol": "BSND",
        "hgnc": "HGNC:16512",
        "name": "barttin CLCNK type accessory subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bsnd"
      },
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "hgnc": "HGNC:1391",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1d"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "clcn2",
        "symbol": "CLCN2",
        "hgnc": "HGNC:2020",
        "name": "chloride voltage-gated channel 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcn2"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "kcnj1",
        "symbol": "KCNJ1",
        "hgnc": "HGNC:6255",
        "name": "potassium inwardly rectifying channel subfamily J member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "kcnj18",
        "symbol": "KCNJ18",
        "hgnc": "HGNC:39080",
        "name": "potassium inwardly rectifying channel subfamily J member 18",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj18"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "serpina6",
        "symbol": "SERPINA6",
        "hgnc": "HGNC:1540",
        "name": "serpin family A member 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpina6"
      },
      {
        "slug": "slc12a1",
        "symbol": "SLC12A1",
        "hgnc": "HGNC:10910",
        "name": "solute carrier family 12 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a1"
      },
      {
        "slug": "slc26a3",
        "symbol": "SLC26A3",
        "hgnc": "HGNC:3018",
        "name": "solute carrier family 26 member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a3"
      },
      {
        "slug": "slc4a4",
        "symbol": "SLC4A4",
        "hgnc": "HGNC:11030",
        "name": "solute carrier family 4 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a4"
      },
      {
        "slug": "atp6v0a4",
        "symbol": "ATP6V0A4",
        "hgnc": "HGNC:866",
        "name": "ATPase H+ transporting V0 subunit a4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v0a4"
      },
      {
        "slug": "atp6v1b1",
        "symbol": "ATP6V1B1",
        "hgnc": "HGNC:853",
        "name": "ATPase H+ transporting V1 subunit B1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b1"
      },
      {
        "slug": "clcnka",
        "symbol": "CLCNKA",
        "hgnc": "HGNC:2026",
        "name": "chloride voltage-gated channel Ka",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcnka"
      },
      {
        "slug": "cyp11b1",
        "symbol": "CYP11B1",
        "hgnc": "HGNC:2591",
        "name": "cytochrome P450 family 11 subfamily B member 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cyp11b1"
      },
      {
        "slug": "hsd11b2",
        "symbol": "HSD11B2",
        "hgnc": "HGNC:5209",
        "name": "hydroxysteroid 11-beta dehydrogenase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hsd11b2"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "cyp17a1",
        "symbol": "CYP17A1",
        "hgnc": "HGNC:2593",
        "name": "cytochrome P450 family 17 subfamily A member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp17a1"
      },
      {
        "slug": "def6",
        "symbol": "DEF6",
        "hgnc": "HGNC:2760",
        "name": "DEF6 guanine nucleotide exchange factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/def6"
      },
      {
        "slug": "ehhadh",
        "symbol": "EHHADH",
        "hgnc": "HGNC:3247",
        "name": "enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ehhadh"
      },
      {
        "slug": "fxyd2",
        "symbol": "FXYD2",
        "hgnc": "HGNC:4026",
        "name": "FXYD domain containing ion transport regulator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fxyd2"
      },
      {
        "slug": "gatm",
        "symbol": "GATM",
        "hgnc": "HGNC:4175",
        "name": "glycine amidinotransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatm"
      },
      {
        "slug": "gemin4",
        "symbol": "GEMIN4",
        "hgnc": "HGNC:15717",
        "name": "gem nuclear organelle associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gemin4"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "nr3c1",
        "symbol": "NR3C1",
        "hgnc": "HGNC:7978",
        "name": "nuclear receptor subfamily 3 group C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr3c1"
      },
      {
        "slug": "nup214",
        "symbol": "NUP214",
        "hgnc": "HGNC:8064",
        "name": "nucleoporin 214",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup214"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "hgnc": "HGNC:19903",
        "name": "Ras related GTP binding D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragd"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "znrf3",
        "symbol": "ZNRF3",
        "hgnc": "HGNC:18126",
        "name": "zinc and ring finger 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znrf3"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "hgnc": "HGNC:1514",
        "name": "calcium sensing receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casr"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "cyp11b2",
        "symbol": "CYP11B2",
        "hgnc": "HGNC:2592",
        "name": "cytochrome P450 family 11 subfamily B member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp11b2"
      },
      {
        "slug": "h6pd",
        "symbol": "H6PD",
        "hgnc": "HGNC:4795",
        "name": "hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h6pd"
      },
      {
        "slug": "hsd11b1",
        "symbol": "HSD11B1",
        "hgnc": "HGNC:5208",
        "name": "hydroxysteroid 11-beta dehydrogenase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd11b1"
      },
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "unc45a",
        "symbol": "UNC45A",
        "hgnc": "HGNC:30594",
        "name": "unc-45 myosin chaperone A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc45a"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "cldn10",
        "symbol": "CLDN10",
        "hgnc": "HGNC:2033",
        "name": "claudin 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn10"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "hgnc": "HGNC:6263",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj2"
      },
      {
        "slug": "maged2",
        "symbol": "MAGED2",
        "hgnc": "HGNC:16353",
        "name": "MAGE family member D2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/maged2"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a2"
      },
      {
        "slug": "smad4",
        "symbol": "SMAD4",
        "hgnc": "HGNC:6770",
        "name": "SMAD family member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad4"
      },
      {
        "slug": "usp8",
        "symbol": "USP8",
        "hgnc": "HGNC:12631",
        "name": "ubiquitin specific peptidase 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp8"
      }
    ]
  }
}