{
  "url": "https://dantelabs.com/traits/hypohidrosis-or-hyperhidrosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypohidrosis-or-hyperhidrosis",
    "id": "HP:0007550",
    "name": "Lack of sweating or excessive sweating",
    "label": "Hypohidrosis or hyperhidrosis",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-skin-adnexa-physiology",
        "name": "Abnormality of skin adnexa physiology",
        "url": "https://dantelabs.com/traits/abnormality-of-skin-adnexa-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "genes": 137,
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "hypohidrosis",
        "name": "Decreased ability to sweat",
        "genes": 82,
        "url": "https://dantelabs.com/traits/hypohidrosis"
      }
    ],
    "genes": [
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "hgnc": "HGNC:24526",
        "name": "atlastin GTPase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl3"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "krt74",
        "symbol": "KRT74",
        "hgnc": "HGNC:28929",
        "name": "keratin 74",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt74"
      }
    ]
  }
}