{
  "url": "https://dantelabs.com/traits/hypochromic-anemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypochromic-anemia",
    "id": "HP:0001931",
    "name": "Hypochromic anemia",
    "definition": "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "anemia-of-inadequate-production",
        "name": "Anemia of inadequate production",
        "url": "https://dantelabs.com/traits/anemia-of-inadequate-production"
      }
    ],
    "narrower": [
      {
        "slug": "iron-deficiency-anemia",
        "name": "Iron deficiency anemia",
        "genes": 35,
        "url": "https://dantelabs.com/traits/iron-deficiency-anemia"
      },
      {
        "slug": "hypochromic-microcytic-anemia",
        "name": "Hypochromic microcytic anemia",
        "genes": 25,
        "url": "https://dantelabs.com/traits/hypochromic-microcytic-anemia"
      }
    ],
    "genes": [
      {
        "slug": "elmo2",
        "symbol": "ELMO2",
        "hgnc": "HGNC:17233",
        "name": "engulfment and cell motility 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elmo2"
      },
      {
        "slug": "ireb2",
        "symbol": "IREB2",
        "hgnc": "HGNC:6115",
        "name": "iron responsive element binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ireb2"
      },
      {
        "slug": "irx5",
        "symbol": "IRX5",
        "hgnc": "HGNC:14361",
        "name": "iroquois homeobox 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irx5"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "cyp27b1",
        "symbol": "CYP27B1",
        "hgnc": "HGNC:2606",
        "name": "cytochrome P450 family 27 subfamily B member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27b1"
      },
      {
        "slug": "cyp2r1",
        "symbol": "CYP2R1",
        "hgnc": "HGNC:20580",
        "name": "cytochrome P450 family 2 subfamily R member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp2r1"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "sf3b1",
        "symbol": "SF3B1",
        "hgnc": "HGNC:10768",
        "name": "splicing factor 3b subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "pus1",
        "symbol": "PUS1",
        "hgnc": "HGNC:15508",
        "name": "pseudouridine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pus1"
      },
      {
        "slug": "tf",
        "symbol": "TF",
        "hgnc": "HGNC:11740",
        "name": "transferrin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tf"
      }
    ]
  }
}