{
  "url": "https://dantelabs.com/traits/hyperostosis-cranialis-interna",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hyperostosis-cranialis-interna",
    "id": "HP:0005890",
    "name": "Enlargement of the inner surface of the skull bones",
    "label": "Hyperostosis cranialis interna",
    "definition": "Bony overgrowth of the internal (endosteal) surface of the calvaria and the base of skull.",
    "synonyms": [
      "Excessive growth of inner surface of the skull bones",
      "Overgrowth of the inner surface of the skull bones",
      "Overgrowth of the inside of the skull",
      "Thick inner surface of the skull bones",
      "Hyperostosis of the internal surface of the cranial bone",
      "Hyperostosis of the internal surface of the cranial bones"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "cranial-hyperostosis",
        "name": "Enlargement of skull bones",
        "url": "https://dantelabs.com/traits/cranial-hyperostosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "tbxas1",
        "symbol": "TBXAS1",
        "hgnc": "HGNC:11609",
        "name": "thromboxane A synthase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxas1"
      },
      {
        "slug": "slc39a14",
        "symbol": "SLC39A14",
        "hgnc": "HGNC:20858",
        "name": "solute carrier family 39 member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a14"
      }
    ]
  }
}