{
  "url": "https://dantelabs.com/traits/hypermethioninemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypermethioninemia",
    "id": "HP:0003235",
    "name": "Increased methionine in blood",
    "label": "Hypermethioninemia",
    "definition": "An increased concentration of methionine in the blood.",
    "synonyms": [
      "Methioninemia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-methionine-concentration",
        "name": "Abnormal circulating methionine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-methionine-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "adk",
        "symbol": "ADK",
        "hgnc": "HGNC:257",
        "name": "adenosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adk"
      },
      {
        "slug": "ahcy",
        "symbol": "AHCY",
        "hgnc": "HGNC:343",
        "name": "adenosylhomocysteinase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ahcy"
      },
      {
        "slug": "cbs",
        "symbol": "CBS",
        "hgnc": "HGNC:1550",
        "name": "cystathionine beta-synthase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbs"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "tfam",
        "symbol": "TFAM",
        "hgnc": "HGNC:11741",
        "name": "transcription factor A, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfam"
      },
      {
        "slug": "fah",
        "symbol": "FAH",
        "hgnc": "HGNC:3579",
        "name": "fumarylacetoacetate hydrolase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fah"
      },
      {
        "slug": "gnmt",
        "symbol": "GNMT",
        "hgnc": "HGNC:4415",
        "name": "glycine N-methyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnmt"
      },
      {
        "slug": "mat1a",
        "symbol": "MAT1A",
        "hgnc": "HGNC:6903",
        "name": "methionine adenosyltransferase 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mat1a"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skic3"
      }
    ]
  }
}