{
  "url": "https://dantelabs.com/traits/fragile-nails",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "fragile-nails",
    "id": "HP:0001808",
    "name": "Brittle nails",
    "label": "Fragile nails",
    "definition": "Nails that easily break.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nail-morphology",
        "name": "Abnormality of the nail",
        "url": "https://dantelabs.com/traits/abnormal-nail-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hephl1",
        "symbol": "HEPHL1",
        "hgnc": "HGNC:30477",
        "name": "hephaestin like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hephl1"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "dlx3",
        "symbol": "DLX3",
        "hgnc": "HGNC:2916",
        "name": "distal-less homeobox 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dlx3"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "prkd1",
        "symbol": "PRKD1",
        "hgnc": "HGNC:9407",
        "name": "protein kinase D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkd1"
      },
      {
        "slug": "smarcd2",
        "symbol": "SMARCD2",
        "hgnc": "HGNC:11107",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit D2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcd2"
      },
      {
        "slug": "trps1",
        "symbol": "TRPS1",
        "hgnc": "HGNC:12340",
        "name": "transcriptional repressor GATA binding 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trps1"
      },
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "hgnc": "HGNC:20",
        "name": "alanyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars1"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "dbr1",
        "symbol": "DBR1",
        "hgnc": "HGNC:15594",
        "name": "debranching RNA lariats 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbr1"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc3",
        "symbol": "ERCC3",
        "hgnc": "HGNC:3435",
        "name": "ERCC excision repair 3, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc3"
      },
      {
        "slug": "fosl2",
        "symbol": "FOSL2",
        "hgnc": "HGNC:3798",
        "name": "FOS like 2, AP-1 transcription factor subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fosl2"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "gtf2h5",
        "symbol": "GTF2H5",
        "hgnc": "HGNC:21157",
        "name": "general transcription factor IIH subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2h5"
      },
      {
        "slug": "mplkip",
        "symbol": "MPLKIP",
        "hgnc": "HGNC:16002",
        "name": "M-phase specific PLK1 interacting protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mplkip"
      },
      {
        "slug": "rnf113a",
        "symbol": "RNF113A",
        "hgnc": "HGNC:12974",
        "name": "ring finger protein 113A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf113a"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "sin3b",
        "symbol": "SIN3B",
        "hgnc": "HGNC:19354",
        "name": "SIN3 transcription regulator family member B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3b"
      },
      {
        "slug": "tars1",
        "symbol": "TARS1",
        "hgnc": "HGNC:11572",
        "name": "threonyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tars1"
      },
      {
        "slug": "camk2g",
        "symbol": "CAMK2G",
        "hgnc": "HGNC:1463",
        "name": "calcium/calmodulin dependent protein kinase II gamma",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2g"
      },
      {
        "slug": "ap1b1",
        "symbol": "AP1B1",
        "hgnc": "HGNC:554",
        "name": "adaptor related protein complex 1 subunit beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1b1"
      },
      {
        "slug": "atp6v0a2",
        "symbol": "ATP6V0A2",
        "hgnc": "HGNC:18481",
        "name": "ATPase H+ transporting V0 subunit a2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v0a2"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "efnb1",
        "symbol": "EFNB1",
        "hgnc": "HGNC:3226",
        "name": "ephrin B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efnb1"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "slurp1",
        "symbol": "SLURP1",
        "hgnc": "HGNC:18746",
        "name": "secreted LY6/PLAUR domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slurp1"
      }
    ]
  }
}