{
  "url": "https://dantelabs.com/traits/cortical-cataract",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "cortical-cataract",
    "id": "HP:0100019",
    "name": "Cortical cataract",
    "definition": "A cataract which affects the layer of the lens surrounding the nucleus, i.e., the lens cortex. It is identified by its unique wedge or spoke appearance.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "zonular-cataract",
        "name": "Zonular cataract",
        "url": "https://dantelabs.com/traits/zonular-cataract"
      }
    ],
    "narrower": [
      {
        "slug": "anterior-cortical-cataract",
        "name": "Anterior cortical cataract",
        "genes": 2,
        "url": "https://dantelabs.com/traits/anterior-cortical-cataract"
      },
      {
        "slug": "posterior-cortical-cataract",
        "name": "Posterior cortical cataract",
        "genes": 2,
        "url": "https://dantelabs.com/traits/posterior-cortical-cataract"
      }
    ],
    "genes": [
      {
        "slug": "bfsp1",
        "symbol": "BFSP1",
        "hgnc": "HGNC:1040",
        "name": "beaded filament structural protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bfsp1"
      },
      {
        "slug": "crygs",
        "symbol": "CRYGS",
        "hgnc": "HGNC:2417",
        "name": "crystallin gamma S",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crygs"
      },
      {
        "slug": "hyal2",
        "symbol": "HYAL2",
        "hgnc": "HGNC:5321",
        "name": "hyaluronidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyal2"
      },
      {
        "slug": "nr6a1",
        "symbol": "NR6A1",
        "hgnc": "HGNC:7985",
        "name": "nuclear receptor subfamily 6 group A member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr6a1"
      },
      {
        "slug": "ubap1l",
        "symbol": "UBAP1L",
        "hgnc": "HGNC:40028",
        "name": "ubiquitin associated protein 1 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap1l"
      },
      {
        "slug": "col18a1",
        "symbol": "COL18A1",
        "hgnc": "HGNC:2195",
        "name": "collagen type XVIII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col18a1"
      },
      {
        "slug": "fzd5",
        "symbol": "FZD5",
        "hgnc": "HGNC:4043",
        "name": "frizzled class receptor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd5"
      },
      {
        "slug": "kiaa1549",
        "symbol": "KIAA1549",
        "hgnc": "HGNC:22219",
        "name": "KIAA1549",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa1549"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "mip",
        "symbol": "MIP",
        "hgnc": "HGNC:7103",
        "name": "major intrinsic protein of lens fiber",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mip"
      },
      {
        "slug": "znf408",
        "symbol": "ZNF408",
        "hgnc": "HGNC:20041",
        "name": "zinc finger protein 408",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf408"
      }
    ]
  }
}