{
  "url": "https://dantelabs.com/traits/chronic-furunculosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "chronic-furunculosis",
    "id": "HP:0011132",
    "name": "Chronic furunculosis",
    "definition": "A furuncle (boil) is a skin infection involving an entire hair follicle and nearby skin tissue. Chronic furunculosis refers to recurrent episodes of furuncles, often caused by recurrent staphylococcus infection.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "recurrent-bacterial-skin-infections",
        "name": "Recurrent bacterial skin infections",
        "url": "https://dantelabs.com/traits/recurrent-bacterial-skin-infections"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "psenen",
        "symbol": "PSENEN",
        "hgnc": "HGNC:30100",
        "name": "presenilin enhancer, gamma-secretase subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psenen"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "il17ra",
        "symbol": "IL17RA",
        "hgnc": "HGNC:5985",
        "name": "interleukin 17 receptor A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17ra"
      },
      {
        "slug": "otulin",
        "symbol": "OTULIN",
        "hgnc": "HGNC:25118",
        "name": "OTU deubiquitinase with linear linkage specificity",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otulin"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      }
    ]
  }
}