{
  "url": "https://dantelabs.com/traits/celiac-disease",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "celiac-disease",
    "id": "HP:0002608",
    "name": "Celiac disease",
    "definition": "Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurrence of CD is seen as a feature of a number of other diseases.",
    "synonyms": [
      "Celiac sprue",
      "Coeliac disease",
      "Coeliac sprue"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-small-intestine-morphology",
        "name": "Abnormal small intestine morphology",
        "url": "https://dantelabs.com/traits/abnormal-small-intestine-morphology"
      },
      {
        "slug": "immunologic-hypersensitivity",
        "name": "Immunologic hypersensitivity",
        "url": "https://dantelabs.com/traits/immunologic-hypersensitivity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cdk4",
        "symbol": "CDK4",
        "hgnc": "HGNC:1773",
        "name": "cyclin dependent kinase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk4"
      },
      {
        "slug": "tbc1d7",
        "symbol": "TBC1D7",
        "hgnc": "HGNC:21066",
        "name": "TBC1 domain family member 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d7"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "arpc5",
        "symbol": "ARPC5",
        "hgnc": "HGNC:708",
        "name": "actin related protein 2/3 complex subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc5"
      },
      {
        "slug": "sgsm3",
        "symbol": "SGSM3",
        "hgnc": "HGNC:25228",
        "name": "small G protein signaling modulator 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgsm3"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "bicra",
        "symbol": "BICRA",
        "hgnc": "HGNC:4332",
        "name": "BRD4 interacting chromatin remodeling complex associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicra"
      },
      {
        "slug": "eln",
        "symbol": "ELN",
        "hgnc": "HGNC:3327",
        "name": "elastin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eln"
      },
      {
        "slug": "gpr35",
        "symbol": "GPR35",
        "hgnc": "HGNC:4492",
        "name": "G protein-coupled receptor 35",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr35"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "ipo8",
        "symbol": "IPO8",
        "hgnc": "HGNC:9853",
        "name": "importin 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ipo8"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "mlxipl",
        "symbol": "MLXIPL",
        "hgnc": "HGNC:12744",
        "name": "MLX interacting protein like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlxipl"
      },
      {
        "slug": "mmel1",
        "symbol": "MMEL1",
        "hgnc": "HGNC:14668",
        "name": "membrane metalloendopeptidase like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmel1"
      },
      {
        "slug": "mst1",
        "symbol": "MST1",
        "hgnc": "HGNC:7380",
        "name": "macrophage stimulating 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mst1"
      },
      {
        "slug": "odc1",
        "symbol": "ODC1",
        "hgnc": "HGNC:8109",
        "name": "ornithine decarboxylase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odc1"
      },
      {
        "slug": "pou2af1",
        "symbol": "POU2AF1",
        "hgnc": "HGNC:9211",
        "name": "POU class 2 homeobox associating factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou2af1"
      },
      {
        "slug": "satb2",
        "symbol": "SATB2",
        "hgnc": "HGNC:21637",
        "name": "SATB homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/satb2"
      },
      {
        "slug": "sema4d",
        "symbol": "SEMA4D",
        "hgnc": "HGNC:10732",
        "name": "semaphorin 4D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema4d"
      },
      {
        "slug": "socs1",
        "symbol": "SOCS1",
        "hgnc": "HGNC:19383",
        "name": "suppressor of cytokine signaling 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/socs1"
      },
      {
        "slug": "spib",
        "symbol": "SPIB",
        "hgnc": "HGNC:11242",
        "name": "Spi-B transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spib"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "tnfsf15",
        "symbol": "TNFSF15",
        "hgnc": "HGNC:11931",
        "name": "TNF superfamily member 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf15"
      },
      {
        "slug": "tnpo3",
        "symbol": "TNPO3",
        "hgnc": "HGNC:17103",
        "name": "transportin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnpo3"
      },
      {
        "slug": "wac",
        "symbol": "WAC",
        "hgnc": "HGNC:17327",
        "name": "WW domain containing adaptor with coiled-coil",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wac"
      },
      {
        "slug": "arl6",
        "symbol": "ARL6",
        "hgnc": "HGNC:13210",
        "name": "ARF like GTPase 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl6"
      },
      {
        "slug": "bbip1",
        "symbol": "BBIP1",
        "hgnc": "HGNC:28093",
        "name": "BBSome interacting protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbip1"
      },
      {
        "slug": "bbs1",
        "symbol": "BBS1",
        "hgnc": "HGNC:966",
        "name": "Bardet-Biedl syndrome 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs1"
      },
      {
        "slug": "bbs10",
        "symbol": "BBS10",
        "hgnc": "HGNC:26291",
        "name": "Bardet-Biedl syndrome 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs10"
      },
      {
        "slug": "bbs12",
        "symbol": "BBS12",
        "hgnc": "HGNC:26648",
        "name": "Bardet-Biedl syndrome 12",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs12"
      },
      {
        "slug": "bbs2",
        "symbol": "BBS2",
        "hgnc": "HGNC:967",
        "name": "Bardet-Biedl syndrome 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs2"
      },
      {
        "slug": "bbs4",
        "symbol": "BBS4",
        "hgnc": "HGNC:969",
        "name": "Bardet-Biedl syndrome 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs4"
      },
      {
        "slug": "bbs5",
        "symbol": "BBS5",
        "hgnc": "HGNC:970",
        "name": "Bardet-Biedl syndrome 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs5"
      },
      {
        "slug": "bbs7",
        "symbol": "BBS7",
        "hgnc": "HGNC:18758",
        "name": "Bardet-Biedl syndrome 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs7"
      },
      {
        "slug": "bbs9",
        "symbol": "BBS9",
        "hgnc": "HGNC:30000",
        "name": "Bardet-Biedl syndrome 9",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs9"
      },
      {
        "slug": "cep19",
        "symbol": "CEP19",
        "hgnc": "HGNC:28209",
        "name": "centrosomal protein 19",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep19"
      },
      {
        "slug": "cep290",
        "symbol": "CEP290",
        "hgnc": "HGNC:29021",
        "name": "centrosomal protein 290",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep290"
      },
      {
        "slug": "cfap418",
        "symbol": "CFAP418",
        "hgnc": "HGNC:27232",
        "name": "cilia and flagella associated protein 418",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap418"
      },
      {
        "slug": "ift172",
        "symbol": "IFT172",
        "hgnc": "HGNC:30391",
        "name": "intraflagellar transport 172",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift172"
      },
      {
        "slug": "ift27",
        "symbol": "IFT27",
        "hgnc": "HGNC:18626",
        "name": "intraflagellar transport 27",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift27"
      },
      {
        "slug": "ift74",
        "symbol": "IFT74",
        "hgnc": "HGNC:21424",
        "name": "intraflagellar transport 74",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift74"
      },
      {
        "slug": "ighg2",
        "symbol": "IGHG2",
        "hgnc": "HGNC:5526",
        "name": "immunoglobulin heavy constant gamma 2 (G2m marker)",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg2"
      },
      {
        "slug": "igkc",
        "symbol": "IGKC",
        "hgnc": "HGNC:5716",
        "name": "immunoglobulin kappa constant",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igkc"
      },
      {
        "slug": "lztfl1",
        "symbol": "LZTFL1",
        "hgnc": "HGNC:6741",
        "name": "leucine zipper transcription factor like 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lztfl1"
      },
      {
        "slug": "mkks",
        "symbol": "MKKS",
        "hgnc": "HGNC:7108",
        "name": "MKKS centrosomal shuttling protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mkks"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "nphp1",
        "symbol": "NPHP1",
        "hgnc": "HGNC:7905",
        "name": "nephrocystin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphp1"
      },
      {
        "slug": "scaper",
        "symbol": "SCAPER",
        "hgnc": "HGNC:13081",
        "name": "S-phase cyclin A associated protein in the ER",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scaper"
      },
      {
        "slug": "sclt1",
        "symbol": "SCLT1",
        "hgnc": "HGNC:26406",
        "name": "sodium channel and clathrin linker 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sclt1"
      },
      {
        "slug": "sdccag8",
        "symbol": "SDCCAG8",
        "hgnc": "HGNC:10671",
        "name": "SHH signaling and ciliogenesis regulator SDCCAG8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdccag8"
      },
      {
        "slug": "trim32",
        "symbol": "TRIM32",
        "hgnc": "HGNC:16380",
        "name": "tripartite motif containing 32",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim32"
      },
      {
        "slug": "ttc8",
        "symbol": "TTC8",
        "hgnc": "HGNC:20087",
        "name": "tetratricopeptide repeat domain 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc8"
      },
      {
        "slug": "wdpcp",
        "symbol": "WDPCP",
        "hgnc": "HGNC:28027",
        "name": "WD repeat containing planar cell polarity effector",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdpcp"
      },
      {
        "slug": "hla-dqa1",
        "symbol": "HLA-DQA1",
        "hgnc": "HGNC:4942",
        "name": "major histocompatibility complex, class II, DQ alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqa1"
      },
      {
        "slug": "hla-dqb1",
        "symbol": "HLA-DQB1",
        "hgnc": "HGNC:4944",
        "name": "major histocompatibility complex, class II, DQ beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqb1"
      },
      {
        "slug": "ivns1abp",
        "symbol": "IVNS1ABP",
        "hgnc": "HGNC:16951",
        "name": "influenza virus NS1A binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivns1abp"
      }
    ]
  }
}