{
  "url": "https://dantelabs.com/traits/broad-nasal-tip",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "broad-nasal-tip",
    "id": "HP:0000455",
    "name": "Broad nasal tip",
    "definition": "Increase in width of the nasal tip.",
    "synonyms": [
      "Broad tip of nose",
      "Broad upturned nose",
      "Broad, upturned nose",
      "Increased breadth of nasal tip",
      "Increased breadth of tip of nose",
      "Increased width of nasal tip",
      "Increased width of tip of nose",
      "Nasal tip, broad",
      "Nasal tip, wide",
      "Wide tip of nose"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nasal-tip-morphology",
        "name": "Abnormality of the nasal tip",
        "url": "https://dantelabs.com/traits/abnormal-nasal-tip-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "arid2",
        "symbol": "ARID2",
        "hgnc": "HGNC:18037",
        "name": "AT-rich interaction domain 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/arid2"
      },
      {
        "slug": "ccnk",
        "symbol": "CCNK",
        "hgnc": "HGNC:1596",
        "name": "cyclin K",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnk"
      },
      {
        "slug": "cdk10",
        "symbol": "CDK10",
        "hgnc": "HGNC:1770",
        "name": "cyclin dependent kinase 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk10"
      },
      {
        "slug": "crnkl1",
        "symbol": "CRNKL1",
        "hgnc": "HGNC:15762",
        "name": "crooked neck pre-mRNA splicing factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crnkl1"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "cul7",
        "symbol": "CUL7",
        "hgnc": "HGNC:21024",
        "name": "cullin 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul7"
      },
      {
        "slug": "exosc2",
        "symbol": "EXOSC2",
        "hgnc": "HGNC:17097",
        "name": "exosome component 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc2"
      },
      {
        "slug": "fbxo28",
        "symbol": "FBXO28",
        "hgnc": "HGNC:29046",
        "name": "F-box protein 28",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo28"
      },
      {
        "slug": "foxp1",
        "symbol": "FOXP1",
        "hgnc": "HGNC:3823",
        "name": "forkhead box P1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxp1"
      },
      {
        "slug": "gatad2b",
        "symbol": "GATAD2B",
        "hgnc": "HGNC:30778",
        "name": "GATA zinc finger domain containing 2B",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gatad2b"
      },
      {
        "slug": "jkamp",
        "symbol": "JKAMP",
        "hgnc": "HGNC:20184",
        "name": "JNK1/MAPK8 associated membrane protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jkamp"
      },
      {
        "slug": "kcnn3",
        "symbol": "KCNN3",
        "hgnc": "HGNC:6292",
        "name": "potassium calcium-activated channel subfamily N member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn3"
      },
      {
        "slug": "ltbp1",
        "symbol": "LTBP1",
        "hgnc": "HGNC:6714",
        "name": "latent transforming growth factor beta binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp1"
      },
      {
        "slug": "mymk",
        "symbol": "MYMK",
        "hgnc": "HGNC:33778",
        "name": "myomaker, myoblast fusion factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mymk"
      },
      {
        "slug": "nacc1",
        "symbol": "NACC1",
        "hgnc": "HGNC:20967",
        "name": "nucleus accumbens associated 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nacc1"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "pgap3",
        "symbol": "PGAP3",
        "hgnc": "HGNC:23719",
        "name": "post-GPI attachment to proteins phospholipase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap3"
      },
      {
        "slug": "pigo",
        "symbol": "PIGO",
        "hgnc": "HGNC:23215",
        "name": "phosphatidylinositol glycan anchor biosynthesis class O",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigo"
      },
      {
        "slug": "pigq",
        "symbol": "PIGQ",
        "hgnc": "HGNC:14135",
        "name": "phosphatidylinositol glycan anchor biosynthesis class Q",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigq"
      },
      {
        "slug": "poc1a",
        "symbol": "POC1A",
        "hgnc": "HGNC:24488",
        "name": "POC1 centriolar protein A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/poc1a"
      },
      {
        "slug": "puf60",
        "symbol": "PUF60",
        "hgnc": "HGNC:17042",
        "name": "poly(U) binding splicing factor 60",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/puf60"
      },
      {
        "slug": "rab3gap1",
        "symbol": "RAB3GAP1",
        "hgnc": "HGNC:17063",
        "name": "RAB3 GTPase activating protein catalytic subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3gap1"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "satb2",
        "symbol": "SATB2",
        "hgnc": "HGNC:21637",
        "name": "SATB homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/satb2"
      },
      {
        "slug": "sh3pxd2b",
        "symbol": "SH3PXD2B",
        "hgnc": "HGNC:29242",
        "name": "SH3 and PX domains 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3pxd2b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tpr",
        "symbol": "TPR",
        "hgnc": "HGNC:12017",
        "name": "translocated promoter region, nuclear basket protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpr"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "washc4",
        "symbol": "WASHC4",
        "hgnc": "HGNC:29174",
        "name": "WASH complex subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/washc4"
      },
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "atp6v0a2",
        "symbol": "ATP6V0A2",
        "hgnc": "HGNC:18481",
        "name": "ATPase H+ transporting V0 subunit a2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp6v0a2"
      },
      {
        "slug": "atp6v1a",
        "symbol": "ATP6V1A",
        "hgnc": "HGNC:851",
        "name": "ATPase H+ transporting V1 subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1a"
      },
      {
        "slug": "atp6v1e1",
        "symbol": "ATP6V1E1",
        "hgnc": "HGNC:857",
        "name": "ATPase H+ transporting V1 subunit E1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp6v1e1"
      },
      {
        "slug": "cdh11",
        "symbol": "CDH11",
        "hgnc": "HGNC:1750",
        "name": "cadherin 11",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdh11"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "hdac8",
        "symbol": "HDAC8",
        "hgnc": "HGNC:13315",
        "name": "histone deacetylase 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hdac8"
      },
      {
        "slug": "kat6a",
        "symbol": "KAT6A",
        "hgnc": "HGNC:13013",
        "name": "lysine acetyltransferase 6A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kat6a"
      },
      {
        "slug": "kdm3b",
        "symbol": "KDM3B",
        "hgnc": "HGNC:1337",
        "name": "lysine demethylase 3B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm3b"
      },
      {
        "slug": "las1l",
        "symbol": "LAS1L",
        "hgnc": "HGNC:25726",
        "name": "LAS1 like ribosome biogenesis factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/las1l"
      },
      {
        "slug": "lrp2",
        "symbol": "LRP2",
        "hgnc": "HGNC:6694",
        "name": "LDL receptor related protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp2"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "phf21a",
        "symbol": "PHF21A",
        "hgnc": "HGNC:24156",
        "name": "PHD finger protein 21A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phf21a"
      },
      {
        "slug": "phf8",
        "symbol": "PHF8",
        "hgnc": "HGNC:20672",
        "name": "PHD finger protein 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phf8"
      },
      {
        "slug": "pigv",
        "symbol": "PIGV",
        "hgnc": "HGNC:26031",
        "name": "phosphatidylinositol glycan anchor biosynthesis class V",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigv"
      },
      {
        "slug": "rnf135",
        "symbol": "RNF135",
        "hgnc": "HGNC:21158",
        "name": "ring finger protein 135",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf135"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "six2",
        "symbol": "SIX2",
        "hgnc": "HGNC:10888",
        "name": "SIX homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six2"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zswim6"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "adamts18",
        "symbol": "ADAMTS18",
        "hgnc": "HGNC:17110",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 18",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts18"
      },
      {
        "slug": "ahdc1",
        "symbol": "AHDC1",
        "hgnc": "HGNC:25230",
        "name": "AT-hook DNA binding motif containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahdc1"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "arid1a",
        "symbol": "ARID1A",
        "hgnc": "HGNC:11110",
        "name": "AT-rich interaction domain 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid1a"
      },
      {
        "slug": "arid1b",
        "symbol": "ARID1B",
        "hgnc": "HGNC:18040",
        "name": "AT-rich interaction domain 1B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/arid1b"
      },
      {
        "slug": "arsl",
        "symbol": "ARSL",
        "hgnc": "HGNC:719",
        "name": "arylsulfatase L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsl"
      },
      {
        "slug": "asxl2",
        "symbol": "ASXL2",
        "hgnc": "HGNC:23805",
        "name": "ASXL transcriptional regulator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl2"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "borcs8",
        "symbol": "BORCS8",
        "hgnc": "HGNC:37247",
        "name": "BLOC-1 related complex subunit 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs8"
      },
      {
        "slug": "cask",
        "symbol": "CASK",
        "hgnc": "HGNC:1497",
        "name": "calcium/calmodulin dependent serine protein kinase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cask"
      },
      {
        "slug": "cog6",
        "symbol": "COG6",
        "hgnc": "HGNC:18621",
        "name": "component of oligomeric golgi complex 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog6"
      },
      {
        "slug": "cplane1",
        "symbol": "CPLANE1",
        "hgnc": "HGNC:25801",
        "name": "ciliogenesis and planar polarity effector complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cplane1"
      },
      {
        "slug": "dock7",
        "symbol": "DOCK7",
        "hgnc": "HGNC:19190",
        "name": "dedicator of cytokinesis 7",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dock7"
      },
      {
        "slug": "dpf2",
        "symbol": "DPF2",
        "hgnc": "HGNC:9964",
        "name": "double PHD fingers 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpf2"
      },
      {
        "slug": "dpyd",
        "symbol": "DPYD",
        "hgnc": "HGNC:3012",
        "name": "dihydropyrimidine dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpyd"
      },
      {
        "slug": "eln",
        "symbol": "ELN",
        "hgnc": "HGNC:3327",
        "name": "elastin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eln"
      },
      {
        "slug": "emilin1",
        "symbol": "EMILIN1",
        "hgnc": "HGNC:19880",
        "name": "elastin microfibril interfacer 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emilin1"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "fam149b1",
        "symbol": "FAM149B1",
        "hgnc": "HGNC:29162",
        "name": "family with sequence similarity 149 member B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam149b1"
      },
      {
        "slug": "frem1",
        "symbol": "FREM1",
        "hgnc": "HGNC:23399",
        "name": "FRAS1 related extracellular matrix 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem1"
      },
      {
        "slug": "gpaa1",
        "symbol": "GPAA1",
        "hgnc": "HGNC:4446",
        "name": "glycosylphosphatidylinositol anchor attachment 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpaa1"
      },
      {
        "slug": "h4c3",
        "symbol": "H4C3",
        "hgnc": "HGNC:4787",
        "name": "H4 clustered histone 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c3"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "hs2st1",
        "symbol": "HS2ST1",
        "hgnc": "HGNC:5193",
        "name": "heparan sulfate 2-O-sulfotransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs2st1"
      },
      {
        "slug": "huwe1",
        "symbol": "HUWE1",
        "hgnc": "HGNC:30892",
        "name": "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/huwe1"
      },
      {
        "slug": "igf1r",
        "symbol": "IGF1R",
        "hgnc": "HGNC:5465",
        "name": "insulin like growth factor 1 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf1r"
      },
      {
        "slug": "kcnk9",
        "symbol": "KCNK9",
        "hgnc": "HGNC:6283",
        "name": "potassium two pore domain channel subfamily K member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk9"
      },
      {
        "slug": "kiaa0753",
        "symbol": "KIAA0753",
        "hgnc": "HGNC:29110",
        "name": "KIAA0753",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0753"
      },
      {
        "slug": "kif7",
        "symbol": "KIF7",
        "hgnc": "HGNC:30497",
        "name": "kinesin family member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif7"
      },
      {
        "slug": "kmt2a",
        "symbol": "KMT2A",
        "hgnc": "HGNC:7132",
        "name": "lysine methyltransferase 2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2a"
      },
      {
        "slug": "knstrn",
        "symbol": "KNSTRN",
        "hgnc": "HGNC:30767",
        "name": "kinetochore localized astrin (SPAG5) binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/knstrn"
      },
      {
        "slug": "mctp2",
        "symbol": "MCTP2",
        "hgnc": "HGNC:25636",
        "name": "multiple C2 and transmembrane domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mctp2"
      },
      {
        "slug": "mlxipl",
        "symbol": "MLXIPL",
        "hgnc": "HGNC:12744",
        "name": "MLX interacting protein like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlxipl"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "ofd1",
        "symbol": "OFD1",
        "hgnc": "HGNC:2567",
        "name": "OFD1 centriole and centriolar satellite protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ofd1"
      },
      {
        "slug": "pde6d",
        "symbol": "PDE6D",
        "hgnc": "HGNC:8788",
        "name": "phosphodiesterase 6D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6d"
      },
      {
        "slug": "pgap2",
        "symbol": "PGAP2",
        "hgnc": "HGNC:17893",
        "name": "post-GPI attachment to proteins 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap2"
      },
      {
        "slug": "phip",
        "symbol": "PHIP",
        "hgnc": "HGNC:15673",
        "name": "PHIP subunit of CUL4-Ring ligase complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phip"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "ptprf",
        "symbol": "PTPRF",
        "hgnc": "HGNC:9670",
        "name": "protein tyrosine phosphatase receptor type F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprf"
      },
      {
        "slug": "qrich1",
        "symbol": "QRICH1",
        "hgnc": "HGNC:24713",
        "name": "glutamine rich 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/qrich1"
      },
      {
        "slug": "rps6ka3",
        "symbol": "RPS6KA3",
        "hgnc": "HGNC:10432",
        "name": "ribosomal protein S6 kinase A3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps6ka3"
      },
      {
        "slug": "setd2",
        "symbol": "SETD2",
        "hgnc": "HGNC:18420",
        "name": "SET domain containing 2, histone lysine methyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/setd2"
      },
      {
        "slug": "smarca4",
        "symbol": "SMARCA4",
        "hgnc": "HGNC:11100",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarca4"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      },
      {
        "slug": "smarcb1",
        "symbol": "SMARCB1",
        "hgnc": "HGNC:11103",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcb1"
      },
      {
        "slug": "smarcc2",
        "symbol": "SMARCC2",
        "hgnc": "HGNC:11105",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit C2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcc2"
      },
      {
        "slug": "smarcd1",
        "symbol": "SMARCD1",
        "hgnc": "HGNC:11106",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcd1"
      },
      {
        "slug": "smarce1",
        "symbol": "SMARCE1",
        "hgnc": "HGNC:11109",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit E1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarce1"
      },
      {
        "slug": "smc3",
        "symbol": "SMC3",
        "hgnc": "HGNC:2468",
        "name": "structural maintenance of chromosomes 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc3"
      },
      {
        "slug": "sox11",
        "symbol": "SOX11",
        "hgnc": "HGNC:11191",
        "name": "SRY-box transcription factor 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox11"
      },
      {
        "slug": "sox4",
        "symbol": "SOX4",
        "hgnc": "HGNC:11200",
        "name": "SRY-box transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox4"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "tfap2a",
        "symbol": "TFAP2A",
        "hgnc": "HGNC:11742",
        "name": "transcription factor AP-2 alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tfap2a"
      },
      {
        "slug": "tlk2",
        "symbol": "TLK2",
        "hgnc": "HGNC:11842",
        "name": "tousled like kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlk2"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "tmem231",
        "symbol": "TMEM231",
        "hgnc": "HGNC:37234",
        "name": "transmembrane protein 231",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem231"
      },
      {
        "slug": "topors",
        "symbol": "TOPORS",
        "hgnc": "HGNC:21653",
        "name": "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/topors"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "bptf",
        "symbol": "BPTF",
        "hgnc": "HGNC:3581",
        "name": "bromodomain PHD finger transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bptf"
      },
      {
        "slug": "caprin1",
        "symbol": "CAPRIN1",
        "hgnc": "HGNC:6743",
        "name": "cell cycle associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/caprin1"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "ctcf",
        "symbol": "CTCF",
        "hgnc": "HGNC:13723",
        "name": "CCCTC-binding factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctcf"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "fbxo11",
        "symbol": "FBXO11",
        "hgnc": "HGNC:13590",
        "name": "F-box protein 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo11"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "gtf3c3",
        "symbol": "GTF3C3",
        "hgnc": "HGNC:4666",
        "name": "general transcription factor IIIC subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf3c3"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "kcnh1",
        "symbol": "KCNH1",
        "hgnc": "HGNC:6250",
        "name": "potassium voltage-gated channel subfamily H member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnh1"
      },
      {
        "slug": "kdm5a",
        "symbol": "KDM5A",
        "hgnc": "HGNC:9886",
        "name": "lysine demethylase 5A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5a"
      },
      {
        "slug": "klhl20",
        "symbol": "KLHL20",
        "hgnc": "HGNC:25056",
        "name": "kelch like family member 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl20"
      },
      {
        "slug": "mab21l1",
        "symbol": "MAB21L1",
        "hgnc": "HGNC:6757",
        "name": "mab-21 like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mab21l1"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "ppp2ca",
        "symbol": "PPP2CA",
        "hgnc": "HGNC:9299",
        "name": "protein phosphatase 2 catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2ca"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "prmt7",
        "symbol": "PRMT7",
        "hgnc": "HGNC:25557",
        "name": "protein arginine methyltransferase 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prmt7"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "rfx7",
        "symbol": "RFX7",
        "hgnc": "HGNC:25777",
        "name": "regulatory factor X7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx7"
      },
      {
        "slug": "rhobtb2",
        "symbol": "RHOBTB2",
        "hgnc": "HGNC:18756",
        "name": "Rho related BTB domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhobtb2"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "set",
        "symbol": "SET",
        "hgnc": "HGNC:10760",
        "name": "SET nuclear proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/set"
      },
      {
        "slug": "smg9",
        "symbol": "SMG9",
        "hgnc": "HGNC:25763",
        "name": "SMG9 nonsense mediated mRNA decay factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smg9"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "supt16h",
        "symbol": "SUPT16H",
        "hgnc": "HGNC:11465",
        "name": "SPT16 homolog, facilitates chromatin remodeling subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/supt16h"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "tbx2",
        "symbol": "TBX2",
        "hgnc": "HGNC:11597",
        "name": "T-box transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx2"
      },
      {
        "slug": "toe1",
        "symbol": "TOE1",
        "hgnc": "HGNC:15954",
        "name": "target of EGR1, exonuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/toe1"
      },
      {
        "slug": "wac",
        "symbol": "WAC",
        "hgnc": "HGNC:17327",
        "name": "WW domain containing adaptor with coiled-coil",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wac"
      },
      {
        "slug": "zbtb20",
        "symbol": "ZBTB20",
        "hgnc": "HGNC:13503",
        "name": "zinc finger and BTB domain containing 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb20"
      },
      {
        "slug": "zfx",
        "symbol": "ZFX",
        "hgnc": "HGNC:12869",
        "name": "zinc finger protein X-linked",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfx"
      },
      {
        "slug": "zmym2",
        "symbol": "ZMYM2",
        "hgnc": "HGNC:12989",
        "name": "zinc finger MYM-type containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmym2"
      },
      {
        "slug": "agl",
        "symbol": "AGL",
        "hgnc": "HGNC:321",
        "name": "amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agl"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "alx3",
        "symbol": "ALX3",
        "hgnc": "HGNC:449",
        "name": "ALX homeobox 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx3"
      },
      {
        "slug": "asxl3",
        "symbol": "ASXL3",
        "hgnc": "HGNC:29357",
        "name": "ASXL transcriptional regulator 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl3"
      },
      {
        "slug": "ccnq",
        "symbol": "CCNQ",
        "hgnc": "HGNC:28434",
        "name": "cyclin Q",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnq"
      },
      {
        "slug": "eif2s3",
        "symbol": "EIF2S3",
        "hgnc": "HGNC:3267",
        "name": "eukaryotic translation initiation factor 2 subunit gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2s3"
      },
      {
        "slug": "flnb",
        "symbol": "FLNB",
        "hgnc": "HGNC:3755",
        "name": "filamin B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnb"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "idua",
        "symbol": "IDUA",
        "hgnc": "HGNC:5391",
        "name": "alpha-L-iduronidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idua"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kif11",
        "symbol": "KIF11",
        "hgnc": "HGNC:6388",
        "name": "kinesin family member 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif11"
      },
      {
        "slug": "kptn",
        "symbol": "KPTN",
        "hgnc": "HGNC:6404",
        "name": "kaptin, actin binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kptn"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k7"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "nxn",
        "symbol": "NXN",
        "hgnc": "HGNC:18008",
        "name": "nucleoredoxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nxn"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rab3gap2",
        "symbol": "RAB3GAP2",
        "hgnc": "HGNC:17168",
        "name": "RAB3 GTPase activating non-catalytic protein subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3gap2"
      },
      {
        "slug": "rarb",
        "symbol": "RARB",
        "hgnc": "HGNC:9865",
        "name": "retinoic acid receptor beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rarb"
      },
      {
        "slug": "tbc1d32",
        "symbol": "TBC1D32",
        "hgnc": "HGNC:21485",
        "name": "TBC1 domain family member 32",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d32"
      },
      {
        "slug": "tfap2b",
        "symbol": "TFAP2B",
        "hgnc": "HGNC:11743",
        "name": "transcription factor AP-2 beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2b"
      },
      {
        "slug": "xrcc4",
        "symbol": "XRCC4",
        "hgnc": "HGNC:12831",
        "name": "X-ray repair cross complementing 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc4"
      }
    ]
  }
}