{
  "url": "https://dantelabs.com/traits/branchial-anomaly",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "branchial-anomaly",
    "id": "HP:0009794",
    "name": "Branchial anomaly",
    "definition": "Congenital developmental defect arising from the primitive branchial apparatus.",
    "synonyms": [
      "Abnormality of branchial apparatus",
      "Abnormality of branchial arch",
      "Branchial abnormality",
      "Branchial anomalies"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-neck-morphology",
        "name": "Abnormal neck morphology",
        "url": "https://dantelabs.com/traits/abnormal-neck-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "branchial-fistula",
        "name": "Branchial fistula",
        "genes": 11,
        "url": "https://dantelabs.com/traits/branchial-fistula"
      },
      {
        "slug": "branchial-cyst",
        "name": "Branchial cyst",
        "genes": 6,
        "url": "https://dantelabs.com/traits/branchial-cyst"
      },
      {
        "slug": "branchial-sinus",
        "name": "Branchial sinus",
        "genes": 5,
        "url": "https://dantelabs.com/traits/branchial-sinus"
      }
    ],
    "genes": [
      {
        "slug": "eya1",
        "symbol": "EYA1",
        "hgnc": "HGNC:3519",
        "name": "EYA transcriptional coactivator and phosphatase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eya1"
      },
      {
        "slug": "six1",
        "symbol": "SIX1",
        "hgnc": "HGNC:10887",
        "name": "SIX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six1"
      },
      {
        "slug": "six5",
        "symbol": "SIX5",
        "hgnc": "HGNC:10891",
        "name": "SIX homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six5"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "wac",
        "symbol": "WAC",
        "hgnc": "HGNC:17327",
        "name": "WW domain containing adaptor with coiled-coil",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wac"
      },
      {
        "slug": "sf3b2",
        "symbol": "SF3B2",
        "hgnc": "HGNC:10769",
        "name": "splicing factor 3b subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b2"
      },
      {
        "slug": "tfap2a",
        "symbol": "TFAP2A",
        "hgnc": "HGNC:11742",
        "name": "transcription factor AP-2 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2a"
      }
    ]
  }
}