{
  "url": "https://dantelabs.com/traits/angular-cheilitis",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "angular-cheilitis",
    "id": "HP:0030318",
    "name": "Inflammation of corners of the mouth",
    "label": "Angular cheilitis",
    "definition": "A type of inflammation of the lips involving one or both of the corners of the mouth.",
    "synonyms": [
      "Red and sore corners of the mouth",
      "Angular cheilosis",
      "Angular stomatitis",
      "Commissural cheilitis",
      "Inflammation of oral commisures"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "cheilitis",
        "name": "Inflammation of the lips",
        "url": "https://dantelabs.com/traits/cheilitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dsc3",
        "symbol": "DSC3",
        "hgnc": "HGNC:3037",
        "name": "desmocollin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsc3"
      },
      {
        "slug": "icoslg",
        "symbol": "ICOSLG",
        "hgnc": "HGNC:17087",
        "name": "inducible T cell costimulator ligand",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/icoslg"
      },
      {
        "slug": "mbtps1",
        "symbol": "MBTPS1",
        "hgnc": "HGNC:15456",
        "name": "membrane bound transcription factor peptidase, site 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps1"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "cast",
        "symbol": "CAST",
        "hgnc": "HGNC:1515",
        "name": "calpastatin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cast"
      },
      {
        "slug": "amn",
        "symbol": "AMN",
        "hgnc": "HGNC:14604",
        "name": "amnion associated transmembrane protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amn"
      },
      {
        "slug": "cubn",
        "symbol": "CUBN",
        "hgnc": "HGNC:2548",
        "name": "cubilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cubn"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srebf1"
      },
      {
        "slug": "tmprss6",
        "symbol": "TMPRSS6",
        "hgnc": "HGNC:16517",
        "name": "transmembrane serine protease 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmprss6"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt17",
        "symbol": "KRT17",
        "hgnc": "HGNC:6427",
        "name": "keratin 17",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt17"
      },
      {
        "slug": "krt6a",
        "symbol": "KRT6A",
        "hgnc": "HGNC:6443",
        "name": "keratin 6A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt6a"
      },
      {
        "slug": "krt6b",
        "symbol": "KRT6B",
        "hgnc": "HGNC:6444",
        "name": "keratin 6B",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt6b"
      }
    ]
  }
}