{
  "url": "https://dantelabs.com/traits/akinesia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "akinesia",
    "id": "HP:0002304",
    "name": "Akinesia",
    "definition": "Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "diminished-movement",
        "name": "Diminished movement",
        "url": "https://dantelabs.com/traits/diminished-movement"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dctn1",
        "symbol": "DCTN1",
        "hgnc": "HGNC:2711",
        "name": "dynactin subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dctn1"
      },
      {
        "slug": "kars1",
        "symbol": "KARS1",
        "hgnc": "HGNC:6215",
        "name": "lysyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kars1"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "rab32",
        "symbol": "RAB32",
        "hgnc": "HGNC:9772",
        "name": "RAB32, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab32"
      },
      {
        "slug": "tor1a",
        "symbol": "TOR1A",
        "hgnc": "HGNC:3098",
        "name": "torsin family 1 member A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tor1a"
      },
      {
        "slug": "vps13c",
        "symbol": "VPS13C",
        "hgnc": "HGNC:23594",
        "name": "vacuolar protein sorting 13 homolog C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13c"
      },
      {
        "slug": "dok7",
        "symbol": "DOK7",
        "hgnc": "HGNC:26594",
        "name": "docking protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dok7"
      },
      {
        "slug": "gldn",
        "symbol": "GLDN",
        "hgnc": "HGNC:29514",
        "name": "gliomedin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gldn"
      },
      {
        "slug": "kif21a",
        "symbol": "KIF21A",
        "hgnc": "HGNC:19349",
        "name": "kinesin family member 21A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif21a"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "musk",
        "symbol": "MUSK",
        "hgnc": "HGNC:7525",
        "name": "muscle associated receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/musk"
      },
      {
        "slug": "myod1",
        "symbol": "MYOD1",
        "hgnc": "HGNC:7611",
        "name": "myogenic differentiation 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myod1"
      },
      {
        "slug": "nup88",
        "symbol": "NUP88",
        "hgnc": "HGNC:8067",
        "name": "nucleoporin 88",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup88"
      },
      {
        "slug": "rapsn",
        "symbol": "RAPSN",
        "hgnc": "HGNC:9863",
        "name": "receptor associated protein of the synapse",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rapsn"
      },
      {
        "slug": "slc18a3",
        "symbol": "SLC18A3",
        "hgnc": "HGNC:10936",
        "name": "solute carrier family 18 member A3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc18a3"
      },
      {
        "slug": "tuba1a",
        "symbol": "TUBA1A",
        "hgnc": "HGNC:20766",
        "name": "tubulin alpha 1a",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba1a"
      },
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "dnajc6",
        "symbol": "DNAJC6",
        "hgnc": "HGNC:15469",
        "name": "DnaJ heat shock protein family (Hsp40) member C6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc6"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "ndufa13",
        "symbol": "NDUFA13",
        "hgnc": "HGNC:17194",
        "name": "NADH:ubiquinone oxidoreductase subunit A13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa13"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "podxl",
        "symbol": "PODXL",
        "hgnc": "HGNC:9171",
        "name": "podocalyxin like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/podxl"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "tmem240",
        "symbol": "TMEM240",
        "hgnc": "HGNC:25186",
        "name": "transmembrane protein 240",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tmem240"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "wdr45",
        "symbol": "WDR45",
        "hgnc": "HGNC:28912",
        "name": "WD repeat domain 45",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr45"
      },
      {
        "slug": "cp",
        "symbol": "CP",
        "hgnc": "HGNC:2295",
        "name": "ceruloplasmin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cp"
      },
      {
        "slug": "fxr1",
        "symbol": "FXR1",
        "hgnc": "HGNC:4023",
        "name": "FMR1 autosomal homolog 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fxr1"
      },
      {
        "slug": "pank2",
        "symbol": "PANK2",
        "hgnc": "HGNC:15894",
        "name": "pantothenate kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pank2"
      },
      {
        "slug": "dpagt1",
        "symbol": "DPAGT1",
        "hgnc": "HGNC:2995",
        "name": "dolichyl-phosphate N-acetylglucosaminephosphotransferase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpagt1"
      },
      {
        "slug": "fgf14",
        "symbol": "FGF14",
        "hgnc": "HGNC:3671",
        "name": "fibroblast growth factor 14",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf14"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "chrna1",
        "symbol": "CHRNA1",
        "hgnc": "HGNC:1955",
        "name": "cholinergic receptor nicotinic alpha 1 subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna1"
      },
      {
        "slug": "chrnd",
        "symbol": "CHRND",
        "hgnc": "HGNC:1965",
        "name": "cholinergic receptor nicotinic delta subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnd"
      },
      {
        "slug": "chrng",
        "symbol": "CHRNG",
        "hgnc": "HGNC:1967",
        "name": "cholinergic receptor nicotinic gamma subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrng"
      },
      {
        "slug": "cntn1",
        "symbol": "CNTN1",
        "hgnc": "HGNC:2171",
        "name": "contactin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntn1"
      },
      {
        "slug": "erbb3",
        "symbol": "ERBB3",
        "hgnc": "HGNC:3431",
        "name": "erb-b2 receptor tyrosine kinase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb3"
      },
      {
        "slug": "flvcr2",
        "symbol": "FLVCR2",
        "hgnc": "HGNC:20105",
        "name": "FLVCR choline and putative heme transporter 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flvcr2"
      }
    ]
  }
}