{
  "url": "https://dantelabs.com/traits/addictive-substance-use",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "addictive-substance-use",
    "id": "HP:0033511",
    "name": "Addictive substance use",
    "definition": "Chronic compulsive drug seeking and continued use despite harmful consequences.",
    "synonyms": [
      "Addictive drug use",
      "Drug addiction"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "addictive-behavior",
        "name": "Addictive behavior",
        "url": "https://dantelabs.com/traits/addictive-behavior"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cst3",
        "symbol": "CST3",
        "hgnc": "HGNC:2475",
        "name": "cystatin C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cst3"
      }
    ]
  }
}