{
  "url": "https://dantelabs.com/traits/acute-encephalopathy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acute-encephalopathy",
    "id": "HP:0006846",
    "name": "Acute encephalopathy",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "encephalopathy",
        "name": "Encephalopathy",
        "url": "https://dantelabs.com/traits/encephalopathy"
      }
    ],
    "narrower": [
      {
        "slug": "reye-syndrome-like-episodes",
        "name": "Reye syndrome-like episodes",
        "genes": 4,
        "url": "https://dantelabs.com/traits/reye-syndrome-like-episodes"
      },
      {
        "slug": "acute-necrotizing-encephalopathy",
        "name": "Acute necrotizing encephalopathy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/acute-necrotizing-encephalopathy"
      }
    ],
    "genes": [
      {
        "slug": "abcb1",
        "symbol": "ABCB1",
        "hgnc": "HGNC:40",
        "name": "ATP binding cassette subfamily B member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb1"
      },
      {
        "slug": "acy1",
        "symbol": "ACY1",
        "hgnc": "HGNC:177",
        "name": "aminoacylase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acy1"
      },
      {
        "slug": "myrf",
        "symbol": "MYRF",
        "hgnc": "HGNC:1181",
        "name": "myelin regulatory factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myrf"
      },
      {
        "slug": "sqor",
        "symbol": "SQOR",
        "hgnc": "HGNC:20390",
        "name": "sulfide quinone oxidoreductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqor"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "ranbp2",
        "symbol": "RANBP2",
        "hgnc": "HGNC:9848",
        "name": "RAN binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ranbp2"
      },
      {
        "slug": "slc22a5",
        "symbol": "SLC22A5",
        "hgnc": "HGNC:10969",
        "name": "solute carrier family 22 member 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a5"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "cog8",
        "symbol": "COG8",
        "hgnc": "HGNC:18623",
        "name": "component of oligomeric golgi complex 8",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cog8"
      },
      {
        "slug": "gcdh",
        "symbol": "GCDH",
        "hgnc": "HGNC:4189",
        "name": "glutaryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcdh"
      },
      {
        "slug": "slc25a15",
        "symbol": "SLC25A15",
        "hgnc": "HGNC:10985",
        "name": "solute carrier family 25 member 15",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a15"
      },
      {
        "slug": "pck1",
        "symbol": "PCK1",
        "hgnc": "HGNC:8724",
        "name": "phosphoenolpyruvate carboxykinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck1"
      },
      {
        "slug": "pck2",
        "symbol": "PCK2",
        "hgnc": "HGNC:8725",
        "name": "phosphoenolpyruvate carboxykinase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck2"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      }
    ]
  }
}