{
  "url": "https://dantelabs.com/traits/abnormal-middle-ear-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-middle-ear-morphology",
    "id": "HP:0008609",
    "name": "Middle ear malformation",
    "label": "Abnormal middle ear morphology",
    "definition": "An abnormality of the morphology or structure of the middle ear.",
    "synonyms": [
      "Morphological abnormality of the middle ear"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-middle-ear",
        "name": "Abnormality of the middle ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-middle-ear"
      }
    ],
    "narrower": [
      {
        "slug": "otitis-media",
        "name": "Middle ear infection",
        "genes": 74,
        "url": "https://dantelabs.com/traits/otitis-media"
      },
      {
        "slug": "cholesteatoma",
        "name": "Cholesteatoma",
        "genes": 13,
        "url": "https://dantelabs.com/traits/cholesteatoma"
      },
      {
        "slug": "abnormality-of-the-middle-ear-ossicles",
        "name": "Abnormality of the middle ear ossicles",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormality-of-the-middle-ear-ossicles"
      },
      {
        "slug": "tympanosclerosis",
        "name": "Tympanosclerosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/tympanosclerosis"
      }
    ],
    "genes": [
      {
        "slug": "eftud2",
        "symbol": "EFTUD2",
        "hgnc": "HGNC:30858",
        "name": "elongation factor Tu GTP binding domain containing 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eftud2"
      },
      {
        "slug": "eya1",
        "symbol": "EYA1",
        "hgnc": "HGNC:3519",
        "name": "EYA transcriptional coactivator and phosphatase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eya1"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "six1",
        "symbol": "SIX1",
        "hgnc": "HGNC:10887",
        "name": "SIX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six1"
      },
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fras1"
      }
    ]
  }
}