{
  "url": "https://dantelabs.com/traits/abnormal-gingiva-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-gingiva-morphology",
    "id": "HP:0000168",
    "name": "Abnormality of the gums",
    "label": "Abnormal gingiva morphology",
    "definition": "Any abnormality of the gingiva (also known as gums).",
    "synonyms": [
      "Abnormality of the gingiva",
      "Gingival abnormality"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-oral-mucosa-morphology",
        "name": "Abnormality of lining of mouth",
        "url": "https://dantelabs.com/traits/abnormal-oral-mucosa-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "gingival-overgrowth",
        "name": "Gum enlargement",
        "genes": 124,
        "url": "https://dantelabs.com/traits/gingival-overgrowth"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "genes": 61,
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "periodontitis",
        "name": "Gum disease",
        "genes": 38,
        "url": "https://dantelabs.com/traits/periodontitis"
      },
      {
        "slug": "gingivitis",
        "name": "Inflamed gums",
        "genes": 36,
        "url": "https://dantelabs.com/traits/gingivitis"
      },
      {
        "slug": "gingival-fibromatosis",
        "name": "Gingival fibromatosis",
        "genes": 20,
        "url": "https://dantelabs.com/traits/gingival-fibromatosis"
      },
      {
        "slug": "gingival-recession",
        "name": "Gingival recession",
        "genes": 7,
        "url": "https://dantelabs.com/traits/gingival-recession"
      },
      {
        "slug": "gingival-cleft",
        "name": "Gingival cleft",
        "genes": 3,
        "url": "https://dantelabs.com/traits/gingival-cleft"
      },
      {
        "slug": "gingival-fragility",
        "name": "Gingival fragility",
        "genes": 3,
        "url": "https://dantelabs.com/traits/gingival-fragility"
      },
      {
        "slug": "gingival-hyperkeratosis",
        "name": "Gingival hyperkeratosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/gingival-hyperkeratosis"
      }
    ],
    "genes": [
      {
        "slug": "ecm1",
        "symbol": "ECM1",
        "hgnc": "HGNC:3153",
        "name": "extracellular matrix protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ecm1"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "dvl1",
        "symbol": "DVL1",
        "hgnc": "HGNC:3084",
        "name": "dishevelled segment polarity protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dvl1"
      },
      {
        "slug": "dvl3",
        "symbol": "DVL3",
        "hgnc": "HGNC:3087",
        "name": "dishevelled segment polarity protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dvl3"
      },
      {
        "slug": "fzd2",
        "symbol": "FZD2",
        "hgnc": "HGNC:4040",
        "name": "frizzled class receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd2"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "wnt5a",
        "symbol": "WNT5A",
        "hgnc": "HGNC:12784",
        "name": "Wnt family member 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt5a"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "perp",
        "symbol": "PERP",
        "hgnc": "HGNC:17637",
        "name": "p53 apoptosis effector related to PMP22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/perp"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      }
    ]
  }
}