{
  "url": "https://dantelabs.com/traits/abnormal-emotional-state",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-emotional-state",
    "id": "HP:0100851",
    "name": "Abnormal emotional state",
    "definition": "A disturbance in the experience or expression of emotion, characterized by alterations in valence, intensity, frequency, or duration. It may also involve emotional responses that are mismatched, exaggerated, or incongruent relative to internal expectations or external contextual stimuli, such as experiencing negative affect in response to neutral or positive events.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-affect",
        "name": "Abnormal affect",
        "url": "https://dantelabs.com/traits/abnormal-affect"
      }
    ],
    "narrower": [
      {
        "slug": "depression",
        "name": "Depression",
        "genes": 464,
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "emotional-dearth",
        "name": "Emotional poverty",
        "genes": 9,
        "url": "https://dantelabs.com/traits/emotional-dearth"
      },
      {
        "slug": "mania",
        "name": "Manic",
        "genes": 6,
        "url": "https://dantelabs.com/traits/mania"
      },
      {
        "slug": "euphoria",
        "name": "Euphoria",
        "genes": 2,
        "url": "https://dantelabs.com/traits/euphoria"
      },
      {
        "slug": "dysregulated-negative-emotional-state",
        "name": "Feeling bad",
        "genes": 1,
        "url": "https://dantelabs.com/traits/dysregulated-negative-emotional-state"
      }
    ],
    "genes": [
      {
        "slug": "ap2m1",
        "symbol": "AP2M1",
        "hgnc": "HGNC:564",
        "name": "adaptor related protein complex 2 subunit mu 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap2m1"
      },
      {
        "slug": "chd2",
        "symbol": "CHD2",
        "hgnc": "HGNC:1917",
        "name": "chromodomain helicase DNA binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd2"
      },
      {
        "slug": "efhc1",
        "symbol": "EFHC1",
        "hgnc": "HGNC:16406",
        "name": "EF-hand domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efhc1"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "hgnc": "HGNC:29433",
        "name": "neurite extension and migration factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexmif"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "slc6a1",
        "symbol": "SLC6A1",
        "hgnc": "HGNC:11042",
        "name": "solute carrier family 6 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a1"
      },
      {
        "slug": "syngap1",
        "symbol": "SYNGAP1",
        "hgnc": "HGNC:11497",
        "name": "synaptic Ras GTPase activating protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syngap1"
      }
    ]
  }
}