{
  "url": "https://dantelabs.com/traits/abnormal-drug-response",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-drug-response",
    "id": "HP:0020169",
    "name": "Abnormal drug response",
    "definition": "An anomalous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "ptpn6",
        "symbol": "PTPN6",
        "hgnc": "HGNC:9658",
        "name": "protein tyrosine phosphatase non-receptor type 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn6"
      },
      {
        "slug": "ces1",
        "symbol": "CES1",
        "hgnc": "HGNC:1863",
        "name": "carboxylesterase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ces1"
      }
    ]
  }
}