{
  "url": "https://dantelabs.com/traits/abnormal-class-switched-memory-b-cell-proportion",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-class-switched-memory-b-cell-proportion",
    "id": "HP:0030386",
    "name": "Abnormal class-switched memory B cell proportion",
    "definition": "A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.",
    "synonyms": [
      "Abnormal proportion of CD19+CD27+IgD- cells",
      "Abnormal proportion of class-switched memory B cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-memory-b-cell-proportion",
        "name": "Abnormal memory B cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-memory-b-cell-proportion"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-class-switched-memory-b-cell-proportion",
        "name": "Decreased class-switched memory B cell proportion",
        "genes": 23,
        "url": "https://dantelabs.com/traits/decreased-class-switched-memory-b-cell-proportion"
      }
    ],
    "genes": []
  }
}