{
  "url": "https://dantelabs.com/traits/abnormal-circulating-tyrosine-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-tyrosine-concentration",
    "id": "HP:0010917",
    "name": "Abnormal circulating tyrosine concentration",
    "definition": "Any deviation from the normal concentration of tyrosine in the blood circulation.",
    "synonyms": [
      "Abnormal tyrosine level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-aromatic-amino-acid-concentration",
        "name": "Abnormal circulating aromatic amino acid concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-aromatic-amino-acid-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "hypertyrosinemia",
        "name": "Increased tyrosine in blood",
        "genes": 7,
        "url": "https://dantelabs.com/traits/hypertyrosinemia"
      }
    ],
    "genes": [
      {
        "slug": "hpd",
        "symbol": "HPD",
        "hgnc": "HGNC:5147",
        "name": "4-hydroxyphenylpyruvate dioxygenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpd"
      },
      {
        "slug": "pnpo",
        "symbol": "PNPO",
        "hgnc": "HGNC:30260",
        "name": "pyridoxamine 5'-phosphate oxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpo"
      }
    ]
  }
}