{
  "url": "https://dantelabs.com/traits/abnormal-circulating-protein-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-protein-concentration",
    "id": "HP:0010876",
    "name": "Blood protein disease",
    "label": "Abnormal circulating protein concentration",
    "definition": "An abnormal level of a circulating protein in the blood.",
    "synonyms": [
      "Abnormal circulating protein level",
      "Abnormality of circulating protein level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-organic-compound-concentration",
        "name": "Abnormal circulating organic compound concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-organic-compound-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-circulating-thyroglobulin-concentration",
        "name": "Abnormal circulating thyroglobulin concentration",
        "genes": 19,
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroglobulin-concentration"
      },
      {
        "slug": "hypoproteinemia",
        "name": "Decreased protein levels in blood",
        "genes": 18,
        "url": "https://dantelabs.com/traits/hypoproteinemia"
      },
      {
        "slug": "abnormal-circulating-c-peptide-concentration",
        "name": "Abnormal circulating C-peptide concentration",
        "genes": 14,
        "url": "https://dantelabs.com/traits/abnormal-circulating-c-peptide-concentration"
      },
      {
        "slug": "abnormal-circulating-apolipoprotein-concentration",
        "name": "Abnormal circulating apolipoprotein concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormal-circulating-apolipoprotein-concentration"
      },
      {
        "slug": "abnormal-circulating-enzyme-concentration",
        "name": "Abnormal circulating enzyme concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormal-circulating-enzyme-concentration"
      },
      {
        "slug": "elevated-circulating-calprotectin-concentration",
        "name": "Elevated circulating calprotectin concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/elevated-circulating-calprotectin-concentration"
      },
      {
        "slug": "elevated-circulating-osteopontin-concentration",
        "name": "Elevated circulating osteopontin concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/elevated-circulating-osteopontin-concentration"
      },
      {
        "slug": "elevated-circulating-scd25-concentration",
        "name": "Elevated circulating sCD25 concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/elevated-circulating-scd25-concentration"
      },
      {
        "slug": "elevated-circulating-sfasl-concentration",
        "name": "Elevated circulating sFASL concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/elevated-circulating-sfasl-concentration"
      },
      {
        "slug": "abnormal-circulating-c-reactive-protein-concentration",
        "name": "Abnormal circulating C-reactive protein concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "elevated-circulating-ccl18-concentration",
        "name": "Elevated circulating CCL18 concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/elevated-circulating-ccl18-concentration"
      },
      {
        "slug": "elevated-circulating-cea-concentration",
        "name": "Elevated circulating CEA concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/elevated-circulating-cea-concentration"
      },
      {
        "slug": "elevated-circulating-serum-amyloid-a-concentration",
        "name": "Elevated circulating serum amyloid A concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/elevated-circulating-serum-amyloid-a-concentration"
      },
      {
        "slug": "abnormal-circulating-alpha-fetoprotein-concentration",
        "name": "Abnormal circulating alpha-fetoprotein concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-alpha-fetoprotein-concentration"
      },
      {
        "slug": "abnormal-circulating-beta-ctx-concentration",
        "name": "Abnormal circulating beta-CTX concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-beta-ctx-concentration"
      },
      {
        "slug": "abnormal-circulating-ferritin-concentration",
        "name": "Abnormal serum ferritin",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-ferritin-concentration"
      },
      {
        "slug": "decreased-circulating-alpha-1-antitrypsin-concentration",
        "name": "Decreased circulating alpha-1-antitrypsin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-alpha-1-antitrypsin-concentration"
      },
      {
        "slug": "decreased-circulating-corticosteroid-binding-globulin-concentration",
        "name": "Decreased circulating corticosteroid-binding globulin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-corticosteroid-binding-globulin-concentration"
      },
      {
        "slug": "decreased-circulating-nt-proanp-concentration",
        "name": "Decreased circulating NT-proANP concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-nt-proanp-concentration"
      },
      {
        "slug": "decreased-circulating-prekallikrein-concentration",
        "name": "Decreased circulating prekallikrein concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-prekallikrein-concentration"
      },
      {
        "slug": "decreased-circulating-progranulin-concentration",
        "name": "Decreased circulating progranulin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-progranulin-concentration"
      },
      {
        "slug": "elevated-circulating-mucin-16-concentration",
        "name": "Elevated circulating mucin 16 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-mucin-16-concentration"
      },
      {
        "slug": "elevated-circulating-myoglobin-concentration",
        "name": "Elevated circulating myoglobin concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-myoglobin-concentration"
      },
      {
        "slug": "elevated-circulating-pinp-concentration",
        "name": "Elevated circulating PINP concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-pinp-concentration"
      },
      {
        "slug": "elevated-circulating-surfactant-protein-concentration",
        "name": "Elevated circulating surfactant protein concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-circulating-surfactant-protein-concentration"
      },
      {
        "slug": "hyperpepsinogenemia-i",
        "name": "Hyperpepsinogenemia I",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperpepsinogenemia-i"
      },
      {
        "slug": "hyperproteinemia",
        "name": "Hyperproteinemia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperproteinemia"
      },
      {
        "slug": "abnormal-circulating-albumin-concentration",
        "name": "Abnormal albumin level",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-albumin-concentration"
      },
      {
        "slug": "abnormal-circulating-amylase-concentration",
        "name": "Abnormal circulating amylase concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-amylase-concentration"
      },
      {
        "slug": "abnormal-circulating-ceruloplasmin-concentration",
        "name": "Abnormal circulating ceruloplasmin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-ceruloplasmin-concentration"
      },
      {
        "slug": "abnormal-circulating-globulin-concentration",
        "name": "Abnormal circulating globulin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-globulin-concentration"
      },
      {
        "slug": "abnormal-circulating-glucose-6-phosphate-dehydrogenase-concentration",
        "name": "Abnormal circulating glucose-6-phosphate dehydrogenase concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-glucose-6-phosphate-dehydrogenase-concentration"
      },
      {
        "slug": "abnormal-circulating-haptoglobin-concentration",
        "name": "Abnormal circulating haptoglobin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-haptoglobin-concentration"
      },
      {
        "slug": "abnormal-circulating-hepcidin-concentration",
        "name": "Abnormal circulating hepcidin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-hepcidin-concentration"
      },
      {
        "slug": "abnormal-circulating-insulin-like-growth-factor-binding-protein-acid-labile-subunit-concentration",
        "name": "Abnormal circulating insulin-like growth factor-binding protein acid labile subunit concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-like-growth-factor-binding-protein-acid-labile-subunit-concentration"
      },
      {
        "slug": "abnormal-circulating-prealbumin-concentration",
        "name": "Abnormal circulating prealbumin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-prealbumin-concentration"
      },
      {
        "slug": "abnormal-circulating-proanp-concentration",
        "name": "Abnormal circulating proANP concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-proanp-concentration"
      },
      {
        "slug": "abnormal-circulating-retinol-binding-protein-concentration",
        "name": "Abnormal circulating retinol-binding protein concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-retinol-binding-protein-concentration"
      },
      {
        "slug": "abnormal-circulating-thyroxine-binding-globulin-concentration",
        "name": "Abnormal circulating thyroxine-binding globulin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroxine-binding-globulin-concentration"
      },
      {
        "slug": "abnormal-kinin-kallikrein-system-component-activity",
        "name": "Abnormal kinin-kallikrein system component activity",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-kinin-kallikrein-system-component-activity"
      }
    ],
    "genes": [
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "csf2rb",
        "symbol": "CSF2RB",
        "hgnc": "HGNC:2436",
        "name": "colony stimulating factor 2 receptor subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2rb"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      }
    ]
  }
}