{
  "url": "https://dantelabs.com/traits/abnormal-choroid-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-choroid-morphology",
    "id": "HP:0000610",
    "name": "Abnormal choroid morphology",
    "definition": "Any structural abnormality of the choroid (the posterior part of the uvea, the middle tunic of the eye, consisting mainly of blood vessels).",
    "synonyms": [
      "Abnormality of the choroid"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-fundus-morphology",
        "name": "Abnormal fundus morphology",
        "url": "https://dantelabs.com/traits/abnormal-fundus-morphology"
      },
      {
        "slug": "abnormal-uvea-morphology",
        "name": "Abnormal uvea morphology",
        "url": "https://dantelabs.com/traits/abnormal-uvea-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-chorioretinal-morphology",
        "name": "Abnormal chorioretinal morphology",
        "genes": 34,
        "url": "https://dantelabs.com/traits/abnormal-chorioretinal-morphology"
      },
      {
        "slug": "choroidal-neovascularization",
        "name": "Choroidal neovascularization",
        "genes": 23,
        "url": "https://dantelabs.com/traits/choroidal-neovascularization"
      },
      {
        "slug": "chorioretinal-scalloped-atrophy",
        "name": "Chorioretinal scalloped atrophy",
        "genes": 8,
        "url": "https://dantelabs.com/traits/chorioretinal-scalloped-atrophy"
      },
      {
        "slug": "choroidal-hemangioma",
        "name": "Choroidal hemangioma",
        "genes": 5,
        "url": "https://dantelabs.com/traits/choroidal-hemangioma"
      },
      {
        "slug": "dark-choroid",
        "name": "Dark choroid",
        "genes": 2,
        "url": "https://dantelabs.com/traits/dark-choroid"
      },
      {
        "slug": "choroid-thickening",
        "name": "Choroid thickening",
        "genes": 1,
        "url": "https://dantelabs.com/traits/choroid-thickening"
      }
    ],
    "genes": [
      {
        "slug": "abca4",
        "symbol": "ABCA4",
        "hgnc": "HGNC:34",
        "name": "ATP binding cassette subfamily A member 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca4"
      },
      {
        "slug": "aldh1a3",
        "symbol": "ALDH1A3",
        "hgnc": "HGNC:409",
        "name": "aldehyde dehydrogenase 1 family member A3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh1a3"
      },
      {
        "slug": "best1",
        "symbol": "BEST1",
        "hgnc": "HGNC:12703",
        "name": "bestrophin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/best1"
      },
      {
        "slug": "cngb3",
        "symbol": "CNGB3",
        "hgnc": "HGNC:2153",
        "name": "cyclic nucleotide gated channel subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cngb3"
      },
      {
        "slug": "crb1",
        "symbol": "CRB1",
        "hgnc": "HGNC:2343",
        "name": "crumbs cell polarity complex component 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crb1"
      },
      {
        "slug": "elovl4",
        "symbol": "ELOVL4",
        "hgnc": "HGNC:14415",
        "name": "ELOVL fatty acid elongase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elovl4"
      },
      {
        "slug": "hla-a",
        "symbol": "HLA-A",
        "hgnc": "HGNC:4931",
        "name": "major histocompatibility complex, class I, A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-a"
      },
      {
        "slug": "mfrp",
        "symbol": "MFRP",
        "hgnc": "HGNC:18121",
        "name": "membrane frizzled-related protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mfrp"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "prom1",
        "symbol": "PROM1",
        "hgnc": "HGNC:9454",
        "name": "prominin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prom1"
      },
      {
        "slug": "prph2",
        "symbol": "PRPH2",
        "hgnc": "HGNC:9942",
        "name": "peripherin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prph2"
      },
      {
        "slug": "prss56",
        "symbol": "PRSS56",
        "hgnc": "HGNC:39433",
        "name": "serine protease 56",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prss56"
      },
      {
        "slug": "rax",
        "symbol": "RAX",
        "hgnc": "HGNC:18662",
        "name": "retina and anterior neural fold homeobox",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rax"
      },
      {
        "slug": "six6",
        "symbol": "SIX6",
        "hgnc": "HGNC:10892",
        "name": "SIX homeobox 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six6"
      },
      {
        "slug": "sox2",
        "symbol": "SOX2",
        "hgnc": "HGNC:11195",
        "name": "SRY-box transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox2"
      },
      {
        "slug": "tmem98",
        "symbol": "TMEM98",
        "hgnc": "HGNC:24529",
        "name": "transmembrane protein 98",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem98"
      },
      {
        "slug": "timp3",
        "symbol": "TIMP3",
        "hgnc": "HGNC:11822",
        "name": "TIMP metallopeptidase inhibitor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timp3"
      },
      {
        "slug": "gnaq",
        "symbol": "GNAQ",
        "hgnc": "HGNC:4390",
        "name": "G protein subunit alpha q",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnaq"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "nod2",
        "symbol": "NOD2",
        "hgnc": "HGNC:5331",
        "name": "nucleotide binding oligomerization domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nod2"
      },
      {
        "slug": "rlbp1",
        "symbol": "RLBP1",
        "hgnc": "HGNC:10024",
        "name": "retinaldehyde binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlbp1"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      }
    ]
  }
}