{
  "url": "https://dantelabs.com/da/genes/wnt1",
  "gene": {
    "slug": "wnt1",
    "symbol": "WNT1",
    "name": "Wnt family member 1",
    "hgnc": "HGNC:12774",
    "summary": null,
    "location": "12q13.12",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "INT1"
    ],
    "ensemblId": "ENSG00000125084",
    "entrezId": 7471,
    "omim": [
      "164820"
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    "uniprot": [
      "P04628"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 48978322,
      "end": 48982620,
      "strand": "+",
      "ensemblTranscript": "ENST00000293549.4",
      "refseqTranscript": "NM_005430.4",
      "ensemblProtein": "ENSP00000293549.3",
      "refseqProtein": "NP_005421.1",
      "exons": [
        {
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          "end": 48978754
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        {
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      "cds": {
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
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      "end": 49375459,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "LYLDT1",
          "ensemblId": "ENSG00000177627",
          "biotype": "protein_coding",
          "start": 48482498,
          "end": 48496524,
          "strand": "+",
          "slug": "lyldt1"
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        {
          "symbol": "OR8S1",
          "ensemblId": "ENSG00000284723",
          "biotype": "protein_coding",
          "start": 48525632,
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          "strand": "+",
          "slug": "or8s1"
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        {
          "symbol": "OR5BS1",
          "ensemblId": "ENSG00000198678",
          "biotype": "protein_coding",
          "start": 48559882,
          "end": 48562956,
          "strand": "+",
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        },
        {
          "symbol": "LALBA",
          "ensemblId": "ENSG00000167531",
          "biotype": "protein_coding",
          "start": 48567684,
          "end": 48571865,
          "strand": "-",
          "slug": "lalba"
        },
        {
          "symbol": "KANSL2",
          "ensemblId": "ENSG00000139620",
          "biotype": "protein_coding",
          "start": 48653211,
          "end": 48682265,
          "strand": "-",
          "slug": "kansl2"
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        {
          "symbol": "CCNT1",
          "ensemblId": "ENSG00000129315",
          "biotype": "protein_coding",
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          "end": 48716998,
          "strand": "-",
          "slug": "ccnt1"
        },
        {
          "symbol": "SPMIP11",
          "ensemblId": "ENSG00000257987",
          "biotype": "protein_coding",
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          "end": 48765790,
          "strand": "+",
          "slug": "spmip11"
        },
        {
          "symbol": "ADCY6",
          "ensemblId": "ENSG00000174233",
          "biotype": "protein_coding",
          "start": 48766191,
          "end": 48789906,
          "strand": "-",
          "slug": "adcy6"
        },
        {
          "symbol": "CACNB3",
          "ensemblId": "ENSG00000167535",
          "biotype": "protein_coding",
          "start": 48813794,
          "end": 48828942,
          "strand": "+",
          "slug": "cacnb3"
        },
        {
          "symbol": "DDX23",
          "ensemblId": "ENSG00000174243",
          "biotype": "protein_coding",
          "start": 48829756,
          "end": 48852842,
          "strand": "-",
          "slug": "ddx23"
        },
        {
          "symbol": "RND1",
          "ensemblId": "ENSG00000172602",
          "biotype": "protein_coding",
          "start": 48857134,
          "end": 48865870,
          "strand": "-",
          "slug": "rnd1"
        },
        {
          "symbol": "ARF3",
          "ensemblId": "ENSG00000134287",
          "biotype": "protein_coding",
          "start": 48903141,
          "end": 48957531,
          "strand": "-",
          "slug": "arf3"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000272822",
          "biotype": "protein_coding",
          "start": 48903503,
          "end": 48957365,
          "strand": "-"
        },
        {
          "symbol": "DRC2",
          "ensemblId": "ENSG00000139537",
          "biotype": "protein_coding",
          "start": 48904105,
          "end": 48931840,
          "strand": "+",
          "slug": "drc2"
        },
        {
          "symbol": "FKBP11",
          "ensemblId": "ENSG00000134285",
          "biotype": "protein_coding",
          "start": 48921518,
          "end": 48927909,
          "strand": "-",
          "slug": "fkbp11"
        },
        {
          "symbol": "WNT10B",
          "ensemblId": "ENSG00000169884",
          "biotype": "protein_coding",
          "start": 48965185,
          "end": 48972669,
          "strand": "-",
          "slug": "wnt10b"
        },
        {
          "symbol": "DDN",
          "ensemblId": "ENSG00000181418",
          "biotype": "protein_coding",
          "start": 48995149,
          "end": 48999375,
          "strand": "-",
          "slug": "ddn"
        },
        {
          "symbol": "PRKAG1",
          "ensemblId": "ENSG00000181929",
          "biotype": "protein_coding",
          "start": 49002272,
          "end": 49018820,
          "strand": "-",
          "slug": "prkag1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288710",
          "biotype": "protein_coding",
          "start": 49002274,
          "end": 49024075,
          "strand": "-"
        },
        {
          "symbol": "KMT2D",
          "ensemblId": "ENSG00000167548",
          "biotype": "protein_coding",
          "start": 49018975,
          "end": 49060794,
          "strand": "-",
          "slug": "kmt2d"
        },
        {
          "symbol": "RHEBL1",
          "ensemblId": "ENSG00000167550",
          "biotype": "protein_coding",
          "start": 49064675,
          "end": 49070127,
          "strand": "-",
          "slug": "rhebl1"
        },
        {
          "symbol": "DHH",
          "ensemblId": "ENSG00000139549",
          "biotype": "protein_coding",
          "start": 49086656,
          "end": 49094807,
          "strand": "-",
          "slug": "dhh"
        },
        {
          "symbol": "LMBR1L",
          "ensemblId": "ENSG00000139636",
          "biotype": "protein_coding",
          "start": 49096550,
          "end": 49110900,
          "strand": "-",
          "slug": "lmbr1l"
        },
        {
          "symbol": "TUBA1B",
          "ensemblId": "ENSG00000123416",
          "biotype": "protein_coding",
          "start": 49127780,
          "end": 49131398,
          "strand": "-",
          "slug": "tuba1b"
        },
        {
          "symbol": "TUBA1A",
          "ensemblId": "ENSG00000167552",
          "biotype": "protein_coding",
          "start": 49184146,
          "end": 49189324,
          "strand": "-",
          "slug": "tuba1a"
        },
        {
          "symbol": "TUBA1C",
          "ensemblId": "ENSG00000167553",
          "biotype": "protein_coding",
          "start": 49188736,
          "end": 49274600,
          "strand": "+",
          "slug": "tuba1c"
        },
        {
          "symbol": "PRPH",
          "ensemblId": "ENSG00000135406",
          "biotype": "protein_coding",
          "start": 49295141,
          "end": 49298686,
          "strand": "+",
          "slug": "prph"
        },
        {
          "symbol": "TROAP",
          "ensemblId": "ENSG00000135451",
          "biotype": "protein_coding",
          "start": 49323165,
          "end": 49331735,
          "strand": "+",
          "slug": "troap"
        },
        {
          "symbol": "C1QL4",
          "ensemblId": "ENSG00000186897",
          "biotype": "protein_coding",
          "start": 49332409,
          "end": 49337227,
          "strand": "-",
          "slug": "c1ql4"
        },
        {
          "symbol": "DNAJC22",
          "ensemblId": "ENSG00000178401",
          "biotype": "protein_coding",
          "start": 49345607,
          "end": 49357546,
          "strand": "+",
          "slug": "dnajc22"
        },
        {
          "symbol": "SPATS2",
          "ensemblId": "ENSG00000123352",
          "biotype": "protein_coding",
          "start": 49366240,
          "end": 49528438,
          "strand": "+",
          "slug": "spats2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "monogenic-early-onset-osteoporosis",
        "name": "Monogen tidlig debuterende osteoporose",
        "diseases": [
          {
            "mondoId": "MONDO:0019409",
            "name": "Osteoporose med debut i ung alder (WNT1-relateret)",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Osteoporose hos børn eller unge voksne med frakturer, knyttet til WNT1-varianter.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/monogenic-early-onset-osteoporosis"
      },
      {
        "slug": "osteogenesis-imperfecta",
        "name": "Osteogenesis Imperfecta",
        "diseases": [
          {
            "mondoId": "MONDO:0019019",
            "name": "Osteogenesis Imperfecta",
            "genes": 34,
            "inheritance": null,
            "description": "En gruppe arvelige bindevævssygdomme, der giver skøre knogler, som let brækker, ofte med blå sclerae, høretab og tandproblemer.",
            "management": "Cykliske intravenøse bisphosphonater (pamidronat, zoledronat); ortopædisk markstiftning af lange knogler; fysioterapi; denosumab (i klinisk brug til OI hos børn); romosozumab (under udvikling); hørekontrol; tandbehandling ved dentinogenesis imperfecta",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/osteogenesis-imperfecta"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "blue-sclerae",
        "name": "Blue outer white part of eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/blue-sclerae"
      },
      {
        "slug": "bone-pain",
        "name": "Bone pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bone-pain"
      },
      {
        "slug": "bowing-of-limbs-due-to-multiple-fractures",
        "name": "Bowing of limbs due to multiple fractures",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bowing-of-limbs-due-to-multiple-fractures"
      },
      {
        "slug": "vertebral-compression-fracture",
        "name": "Compression fracture of a vertebral body",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vertebral-compression-fracture"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "platyspondyly",
        "name": "Flattened vertebrae",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/platyspondyly"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "kyphosis",
        "name": "Hunched back",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/kyphosis"
      },
      {
        "slug": "hypoplasia-of-the-pons",
        "name": "Hypoplasia of the pons",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-pons"
      },
      {
        "slug": "osteoporosis",
        "name": "Osteoporosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/osteoporosis"
      },
      {
        "slug": "recurrent-fractures",
        "name": "Recurrent fractures",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-fractures"
      },
      {
        "slug": "schizencephaly",
        "name": "Schizencephaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/schizencephaly"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "thin-ribs",
        "name": "Thin ribs",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/thin-ribs"
      }
    ],
    "related": [
      {
        "slug": "ano5",
        "symbol": "ANO5",
        "name": "anoctamin 5",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/ano5"
      },
      {
        "slug": "atp6v0a2",
        "symbol": "ATP6V0A2",
        "name": "ATPase H+ transporting V0 subunit a2",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/atp6v0a2"
      },
      {
        "slug": "bmp1",
        "symbol": "BMP1",
        "name": "bone morphogenetic protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/bmp1"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "name": "collagen type I alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/col1a1"
      },
      {
        "slug": "col1a2",
        "symbol": "COL1A2",
        "name": "collagen type I alpha 2 chain",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/col1a2"
      },
      {
        "slug": "creb3l1",
        "symbol": "CREB3L1",
        "name": "cAMP responsive element binding protein 3 like 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/creb3l1"
      },
      {
        "slug": "crtap",
        "symbol": "CRTAP",
        "name": "cartilage associated protein",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/crtap"
      },
      {
        "slug": "fkbp10",
        "symbol": "FKBP10",
        "name": "FKBP prolyl isomerase 10",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fkbp10"
      },
      {
        "slug": "gorab",
        "symbol": "GORAB",
        "name": "golgin, RAB6 interacting",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/gorab"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "name": "interferon induced with helicase C domain 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/ifih1"
      },
      {
        "slug": "ifitm5",
        "symbol": "IFITM5",
        "name": "interferon induced transmembrane protein 5",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/ifitm5"
      },
      {
        "slug": "kdelr2",
        "symbol": "KDELR2",
        "name": "KDEL endoplasmic reticulum protein retention receptor 2",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kdelr2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}