{
  "url": "https://dantelabs.com/da/genes/trdn",
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      {
        "slug": "catecholaminergic-polymorphic-ventricular-tachycardia",
        "name": "Katekolaminerget polymorf ventrikulær takykardi",
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          {
            "mondoId": "MONDO:0008648",
            "name": "Familiær ventrikulær takykardi",
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            "inheritance": null,
            "description": "Et tilfælde af ventrikulær takykardi, som skyldes en arvelig ændring i personens genom.",
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                "PanelApp Australia"
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          {
            "mondoId": "MONDO:0020575",
            "name": "Polymorf ventrikulær takykardi",
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            "inheritance": null,
            "description": "En ventrikulær takykardi med uregelmæssig frekvens og rytme.",
            "management": null,
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                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
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              "inheritance": [
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              "actionability": 12
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            "sameAsReport": false,
            "broad": false
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        "url": "https://dantelabs.com/da/conditions/catecholaminergic-polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "long-qt-syndrome",
        "name": "Long QT-syndrom",
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            "mondoId": "MONDO:0002442",
            "name": "Long QT-syndrom",
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            "inheritance": null,
            "description": "En forstyrrelse af hjertets repolarisering, kendetegnet ved et forlænget QT-interval og en risiko for farlige ventrikulære arytmier, såsom torsades de pointes.",
            "management": "Betablokkere, ICD-implantation, aktivitetsbegrænsning, genetisk rådgivning",
            "evidence": {
              "gencc": [
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                "G2P"
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              "clingen": "Strong",
              "acmgSf": true,
              "inheritance": [
                "autosomal-recessive"
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            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/long-qt-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "atrial-standstill",
        "name": "Atrial standstill",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atrial-standstill"
      },
      {
        "slug": "bidirectional-ventricular-tachycardia",
        "name": "Bidirectional ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bidirectional-ventricular-tachycardia"
      },
      {
        "slug": "effort-induced-polymorphic-ventricular-tachycardia",
        "name": "Effort-induced polymorphic ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/effort-induced-polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "premature-ventricular-contraction",
        "name": "Extra heart beat",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/premature-ventricular-contraction"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "cardiac-arrest",
        "name": "Heart stops beating",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cardiac-arrest"
      },
      {
        "slug": "atrioventricular-block",
        "name": "Interruption of electrical communication between upper and lower chambers of heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atrioventricular-block"
      },
      {
        "slug": "paroxysmal-atrial-fibrillation",
        "name": "Paroxysmal atrial fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paroxysmal-atrial-fibrillation"
      },
      {
        "slug": "polymorphic-ventricular-tachycardia",
        "name": "Polymorphic ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "proximal-muscle-weakness",
        "name": "Proximal neurogenic muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/proximal-muscle-weakness"
      },
      {
        "slug": "reduced-systolic-function",
        "name": "Reduced systolic function",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/reduced-systolic-function"
      },
      {
        "slug": "shock",
        "name": "Shock",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/shock"
      },
      {
        "slug": "sick-sinus-syndrome",
        "name": "Sick sinus syndrome",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sick-sinus-syndrome"
      },
      {
        "slug": "dilated-cardiomyopathy",
        "name": "Stretched and thinned heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dilated-cardiomyopathy"
      },
      {
        "slug": "sudden-cardiac-death",
        "name": "Sudden cardiac death",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sudden-cardiac-death"
      },
      {
        "slug": "ventricular-couplet",
        "name": "Ventricular couplet",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventricular-couplet"
      },
      {
        "slug": "ventricular-tachycardia",
        "name": "Ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/ventricular-tachycardia"
      }
    ],
    "related": [
      {
        "slug": "calm1",
        "symbol": "CALM1",
        "name": "calmodulin 1",
        "shared": 3,
        "url": "https://dantelabs.com/da/genes/calm1"
      },
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "name": "calmodulin 2",
        "shared": 3,
        "url": "https://dantelabs.com/da/genes/calm2"
      },
      {
        "slug": "calm3",
        "symbol": "CALM3",
        "name": "calmodulin 3",
        "shared": 3,
        "url": "https://dantelabs.com/da/genes/calm3"
      },
      {
        "slug": "casq2",
        "symbol": "CASQ2",
        "name": "calsequestrin 2",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/casq2"
      },
      {
        "slug": "ryr2",
        "symbol": "RYR2",
        "name": "ryanodine receptor 2",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/ryr2"
      },
      {
        "slug": "tecrl",
        "symbol": "TECRL",
        "name": "trans-2,3-enoyl-CoA reductase like",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/tecrl"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/cacna1c"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kcne1"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kcnh2"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kcnj2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kcnq1"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/scn5a"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 8,
    "url": "https://dantelabs.com/genes/trdn/variants",
    "items": [
      {
        "slug": "c-22plus29a-g",
        "name": "c.22+29A>G",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 123636725,
        "grch37Position": 123957870,
        "part": {
          "kind": "intron",
          "number": 1
        },
        "url": "https://dantelabs.com/genes/trdn/variants/c-22plus29a-g"
      },
      {
        "slug": "c-391plus1g-a",
        "name": "c.391+1G>A",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "likely-pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 123548453,
        "grch37Position": 123869598,
        "part": {
          "kind": "intron",
          "number": 3
        },
        "url": "https://dantelabs.com/genes/trdn/variants/c-391plus1g-a"
      },
      {
        "slug": "c-550plus1to550plus2insa",
        "name": "c.550+1_550+2insA",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "likely-pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 123516139,
        "grch37Position": 123837284,
        "part": {
          "kind": "intron",
          "number": 6
        },
        "url": "https://dantelabs.com/genes/trdn/variants/c-550plus1to550plus2insa"
      },
      {
        "slug": "d18afs14",
        "name": "D18Afs*14",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": "c.53_56del",
        "position": 123571098,
        "grch37Position": 123892243,
        "part": {
          "kind": "exon",
          "number": 2
        },
        "url": "https://dantelabs.com/genes/trdn/variants/d18afs14"
      },
      {
        "slug": "e168x",
        "name": "E168X",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic-likely-pathogenic",
        "stars": 2,
        "hgvsC": "c.502G>T",
        "position": 123516189,
        "grch37Position": 123837334,
        "part": {
          "kind": "exon",
          "number": 6
        },
        "url": "https://dantelabs.com/genes/trdn/variants/e168x"
      },
      {
        "slug": "e178kfs45",
        "name": "E178Kfs*45",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic-likely-pathogenic",
        "stars": 2,
        "hgvsC": "c.531del",
        "position": 123516159,
        "grch37Position": 123837304,
        "part": {
          "kind": "exon",
          "number": 6
        },
        "url": "https://dantelabs.com/genes/trdn/variants/e178kfs45"
      },
      {
        "slug": "q205x",
        "name": "Q205X",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": "c.613C>T",
        "position": 123503899,
        "grch37Position": 123825044,
        "part": {
          "kind": "exon",
          "number": 8
        },
        "url": "https://dantelabs.com/genes/trdn/variants/q205x"
      },
      {
        "slug": "v162lfs13",
        "name": "V162Lfs*13",
        "commonName": null,
        "symbol": "TRDN",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": "c.483del",
        "position": 123530506,
        "grch37Position": 123851651,
        "part": {
          "kind": "exon",
          "number": 5
        },
        "url": "https://dantelabs.com/genes/trdn/variants/v162lfs13"
      }
    ]
  }
}