{
  "url": "https://dantelabs.com/da/genes/tecta",
  "gene": {
    "slug": "tecta",
    "symbol": "TECTA",
    "name": "tectorin alpha",
    "hgnc": "HGNC:11720",
    "summary": null,
    "location": "11q23.3",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
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      "DFNA8",
      "DFNB21"
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    "entrezId": 7007,
    "omim": [
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    "uniprot": [
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      "ensemblTranscript": "ENST00000392793.6",
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      "ensemblProtein": "ENSP00000376543.1",
      "refseqProtein": "NP_005413.2",
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      ],
      "cds": {
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        "end": 121190806
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 120971882,
      "end": 121062202,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 120646367,
      "end": 121646366,
      "genes": [
        {
          "symbol": "GRIK4",
          "ensemblId": "ENSG00000149403",
          "biotype": "protein_coding",
          "start": 120511709,
          "end": 120988906,
          "strand": "+",
          "slug": "grik4"
        },
        {
          "symbol": "TBCEL",
          "ensemblId": "ENSG00000154114",
          "biotype": "protein_coding",
          "start": 121024070,
          "end": 121092082,
          "strand": "+",
          "slug": "tbcel"
        },
        {
          "symbol": "TBCEL-TECTA",
          "ensemblId": "ENSG00000285509",
          "biotype": "protein_coding",
          "start": 121024125,
          "end": 121113108,
          "strand": "+",
          "slug": "tbcel-tecta"
        },
        {
          "symbol": "SC5D",
          "ensemblId": "ENSG00000109929",
          "biotype": "protein_coding",
          "start": 121292681,
          "end": 121313410,
          "strand": "+",
          "slug": "sc5d"
        },
        {
          "symbol": "SORL1",
          "ensemblId": "ENSG00000137642",
          "biotype": "protein_coding",
          "start": 121451581,
          "end": 121633763,
          "strand": "+",
          "slug": "sorl1"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Høretab og døvhed",
        "diseases": [
          {
            "mondoId": "MONDO:0019587",
            "name": "Autosomalt dominant ikke-syndromalt høretab",
            "genes": 39,
            "inheritance": "autosomal-dominant",
            "description": "Autosomalt dominant form for ikke-syndromal døvhed.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0019497",
            "name": "Ikke-syndromal genetisk høretab",
            "genes": 97,
            "inheritance": null,
            "description": "Arvelig høretab uden andre medicinske træk, herunder de hyppige recessive former forårsaget af GJB2, OTOF, SLC26A4, STRC og mange andre gener, samt dominante, X-bundne og mitokondrielle former.",
            "management": "Viden om den genetiske årsag kan vejlede valget af høreapparat og cochleaimplantat, berettigelse til genterapiforsøg (for eksempel OTOF) og familierådgivning.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/da/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/actg1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/atp2b2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/cd164"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/ceacam16"
      },
      {
        "slug": "coch",
        "symbol": "COCH",
        "name": "cochlin",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/coch"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "name": "collagen type XI alpha 1 chain",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/col11a1"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "name": "collagen type XI alpha 2 chain",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/col11a2"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/diaph1"
      },
      {
        "slug": "eya4",
        "symbol": "EYA4",
        "name": "EYA transcriptional coactivator and phosphatase 4",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/eya4"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 2,
        "url": "https://dantelabs.com/da/genes/gjb6"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 1,
    "url": "https://dantelabs.com/genes/tecta/variants",
    "items": [
      {
        "slug": "w1362x",
        "name": "W1362X",
        "commonName": null,
        "symbol": "TECTA",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.4085G>A",
        "position": 121146096,
        "grch37Position": 121016805,
        "part": {
          "kind": "exon",
          "number": 12
        },
        "url": "https://dantelabs.com/genes/tecta/variants/w1362x"
      }
    ]
  }
}